STUDY OF OCULAR GLIAL CELLS INVOLVEMENT IN UVEITIS

眼神经胶质细胞参与葡萄膜炎的研究

• 批准号: 3918826
• 负责人: F ROBERGE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918826
• 关键词: T lymphocyte; cell cell interaction; cellular pathology; glia; glucocorticoids; helper T lymphocyte; immunopathology; immunopharmacology; inflammation; interleukin 1; retina; surface antigens; tissue /cell culture; uvea; uveitis

The work extended our ongoing study of interactions between the retinal glial Muller cell and T-lymphocytes. In an in vitro co- culture system, Muller cells had been shown to exert a profound inhibitory influence on the proliferation of T-helper cell lines through a membrane bound factor. Investigations of the nature of the inhibitory moiety revealed that it was sensitive to proteinase. Further studies showed that the expression of the factor on the surface of Muller cells could be suppressed by glucocorticoids.

这项工作扩展了我们正在进行的研究， 视网膜神经胶质Muller细胞和T淋巴细胞。 在体外共- 培养系统中，Muller细胞已被证明发挥了深刻的作用。 对T辅助细胞系增殖的抑制作用 通过膜结合因子。 调查的性质 抑制部分显示其对蛋白酶敏感。 进一步的研究表明，该因子在细胞膜上的表达， 糖皮质激素可抑制Müller细胞表面的生长。