STUDY OF OCULAR GLIAL CELLS INVOLVEMENT IN UVEITIS

眼神经胶质细胞参与葡萄膜炎的研究

• 批准号: 3965399
• 负责人: F ROBERGE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965399
• 关键词: T lymphocyte; cell cell interaction; cellular pathology; glia; helper T lymphocyte; immunopathology; immunopharmacology; inflammation; retina; surface antigens; tissue /cell culture; uvea; uveitis

The work concerns uveoretinal inflammatory disease mechanisms. The study focused on evaluating the role of resident cells at the target organ level. Muller cells interactions with T-lymphocyte cell line was studied in vitro. Two opposite effects of Muller cells on T-lymphocytes proliferation were found that could be expressed under different culture conditions. An inhibitory effect on antigen driven poliferation of T-helper lymphocytes could be modulated with various drugs that allowed the Muller cells to function as antigen presenting cells.

这项工作涉及葡萄膜视网膜炎性疾病的机制。 研究 专注于评估常驻细胞在靶器官中的作用， 水平 研究了Muller细胞与T淋巴细胞系的相互作用 体外 Muller细胞对T淋巴细胞的两种相反作用 在不同的培养条件下， 条件 对抗原驱动的多聚化的抑制作用 辅助性T淋巴细胞可以用各种药物调节， Muller细胞作为抗原呈递细胞发挥功能。