STUDY OF OCULAR GLIAL CELLS INVOLVEMENT IN UVEITIS

眼神经胶质细胞参与葡萄膜炎的研究

• 批准号: 3941670
• 负责人: F ROBERGE
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3941670
• 关键词: T lymphocyte; cell cell interaction; cellular pathology; glia; helper T lymphocyte; immunopathology; immunopharmacology; inflammation; retina; surface antigens; tissue /cell culture; uvea; uveitis

The work extended our ongoing study of interactions between the retinal glial Muller cell and T lymphocytes. In an in vitro co- culture system, Muller cells had been shown to exert a profound inhibitory influence on antigen and IL-2 driven proliferation of T helper cell lines. Investigations of the nature of the inhibitory moiety revealed that it was sensitive to proteinase. In further studies, we demonstrated that Muller cells can produce interleukin 1 (IL-1) activity and that in conditions where their inhibitory action is removed they display the capacity to efficiently function as antigen presenting cells.

这项工作扩展了我们正在进行的研究， 视网膜神经胶质Muller细胞和T淋巴细胞。 在体外共- 培养系统中，Muller细胞已被证明发挥了深刻的作用。 对抗原和IL-2驱动T细胞增殖的抑制作用 辅助细胞系 研究了抑制剂的性质， 结果表明，该酶对蛋白酶敏感。 进一步 研究表明，Muller细胞可以产生 白细胞介素1（IL-1）活性以及在其 抑制作用被移除，它们显示出 有效地作为抗原呈递细胞发挥功能。