Controlled release therapeutic coatings for orthopaedic devices based upon novel sol-gel formulations

感染是关节置换手术的主要并发症，据报道，初次手术后感染的发生率约为1-2%。根除感染的治疗费用对患者和机构来说都是巨大的，就临床费用而言，通常高达主要干预措施的4-5倍。因此，预防感染是强制性的，使用抗生素进行预防具有重要作用。在骨水泥型关节置换手术中，抗生素在关键的围手术期从骨水泥中洗脱出来。然而，在英国，骨水泥型髋关节的数量从54%下降到36%，而非骨水泥型髋关节置换术的数量则从22%增加到43%。非骨水泥生物固定的概念特别有吸引力，特别是对年轻和活跃的患者，因此需要在非骨水泥植入物上覆盖抗生素释放涂层。

Infection is a major complication of arthroplasty surgery with a reported incidence after primary surgery of approx 1-2%. The costs of treatment to eradicate infection are substantial to both patient and institution, and in terms of clinical expenditure are typically up to 4-5 times that of the primary intervention. Prevention of infection is therefore mandatory and prophylaxis with antibiotics plays a significant role. In cemented arthroplasty surgery, antibiotics elute from the bone cement during the crucial early perioperative period. However, the number of cemented hips in the UK has dropped from 54 to 36% while cementless arthroplasty has increased from 22 to 43%. The concept of cementless biological fixation is particularly attractive, especially for the young and active patient, hence the need for an antibiotic-release coating on cementless implants.