Controlled release therapeutic coatings for orthopaedic devices based upon novel sol-gel formulations

基于新型溶胶-凝胶配方的骨科器械控释治疗涂层

• 批准号: MR/J014656/1
• 负责人: Robert Akid
• 金额: $ 50.89万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FJ014656%2F1
• 关键词: Controlled; release; therapeutic; coatings; orthopaedic

Infection is a major complication of arthroplasty surgery with a reported incidence after primary surgery of approx 1-2%. The costs of treatment to eradicate infection are substantial to both patient and institution, and in terms of clinical expenditure are typically up to 4-5 times that of the primary intervention. Prevention of infection is therefore mandatory and prophylaxis with antibiotics plays a significant role. In cemented arthroplasty surgery, antibiotics elute from the bone cement during the crucial early perioperative period. However, the number of cemented hips in the UK has dropped from 54 to 36% while cementless arthroplasty has increased from 22 to 43%. The concept of cementless biological fixation is particularly attractive, especially for the young and active patient, hence the need for an antibiotic-release coating on cementless implants.

感染是关节置换术的主要并发症，据报道，初次手术后感染的发生率约为1-2%。根除感染的治疗费用对患者和机构来说都是巨大的，就临床支出而言，通常高达初级干预措施的4-5倍。因此，预防感染是强制性的，抗生素预防起着重要作用。在骨水泥置换手术中，抗生素在关键的围手术期早期从骨水泥中洗脱。然而，在英国，骨水泥髋关节的数量从54%下降到36%，而无骨水泥关节置换术从22%上升到43%。无骨水泥生物固定的概念特别有吸引力，特别是对于年轻和活跃的患者，因此需要在无骨水泥植入物上使用抗生素释放涂层。

项目成果

The antimicrobial activity and biocompatibility of a controlled gentamicin-releasing single-layer sol-gel coating on hydroxyapatite-coated titanium.

• DOI: 10.1302/0301-620x.103b3.bjj-2020-0347.r1
• 发表时间: 2021-03
• 期刊: The bone & joint journal
• 作者: Nichol T;Callaghan J;Townsend R;Stockley I;Hatton PV;Le Maitre C;Smith TJ;Akid R
• 通讯作者: Akid R