Controlled release therapeutic coatings for orthopaedic devices based upon novel sol-gel formulations

感染是关节置换术的主要并发症，初次手术后报告的发生率约为1- 2%。根除感染的治疗费用对患者和机构来说都很大，就临床支出而言，通常高达初级干预的4-5倍。因此，预防感染是强制性的，抗生素预防起着重要作用。在骨水泥型关节成形术中，抗生素在关键的早期围手术期从骨水泥中排出。然而，在英国，骨水泥型髋关节的数量从54%下降到36%，而非骨水泥型髋关节置换术从22%增加到43%。非骨水泥型生物固定的概念特别有吸引力，尤其是对于年轻活跃的患者，因此需要在非骨水泥型植入物上使用防粘连涂层。

Infection is a major complication of arthroplasty surgery with a reported incidence after primary surgery of approx 1-2%. The costs of treatment to eradicate infection are substantial to both patient and institution, and in terms of clinical expenditure are typically up to 4-5 times that of the primary intervention. Prevention of infection is therefore mandatory and prophylaxis with antibiotics plays a significant role. In cemented arthroplasty surgery, antibiotics elute from the bone cement during the crucial early perioperative period. However, the number of cemented hips in the UK has dropped from 54 to 36% while cementless arthroplasty has increased from 22 to 43%. The concept of cementless biological fixation is particularly attractive, especially for the young and active patient, hence the need for an antibiotic-release coating on cementless implants.