Centre for Musculoskeletal Ageing Research

肌肉骨骼衰老研究中心

• 批准号: MR/K00414X/1
• 负责人: Janet Lord
• 金额: $ 391.9万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK00414X%2F1
• 关键词: Centre; Musculoskeletal; Ageing; Research

Ageing is a complex process that results in the reduced functioning of most of the body's organ systems, with the musculoskeletal system (muscle, bone, tendon and cartilage) significantly affected. The musculoskeletal system is compromised not only by loss of muscle, bone and cartilage with age, but also by the decline in function of the nervous system which results in reduced control of movement and balance. Ageing is also often accompanied by weight gain which puts further strain on joints and contributes to erosion of cartilage and bone, increasing the chances of developing Osteoarthritis (OA). Importantly both ageing and obesity decrease physical activity levels and increase the level of inflammation in the body and alter hormone balance, all of which affect the ability of the body to maintain the musculoskeletal system. Therefore increased physical activity and interventions that are able to reduce inflammation and correct age and obesity related hormone changes, offer a way forward for delaying age-related changes in the musculoskeletal system. Objectives: The objective is to set up a Centre of Excellence in Musculoskeletal Ageing Research by integrating and expanding the complementary research and postgraduate training activity of the two leading Midlands based Universities, Birmingham and Nottingham, together with their associated NHS hospital trusts. The Centre will also establish a unique technical facility for measuring human muscle, tendon and bone metabolism that will provide a valuable resource for the UK research community. The Centre's over-arching research aim is to understand how ageing results in loss of musculoskeletal function and to use this knowledge to intervene and minimise age-related musculoskeletal decline and disease. The major focus of these interventions will be exercise and diet. Clinical benefits: The potential clinical benefits of the research carried out by the Centre are significant as age-related loss of musculoskeletal function has major clinical consequences, including increased risk of falls and fracture (hip and wrist), OA and pain. 1 in 3 older adults fall each year and for 76,000 patients this results in hip fracture. Hip fracture is associated with increased morbidity, loss of independence and the 1 year mortality figure for hip fracture is 22%. There are 6 million people with OA in the UK1, a painful condition which reduces the ability to work and has a significant impact upon quality of life. OA is exacerbated by obesity and there are currently no treatments other than pain remediation.Research questions: 1. What are the key factors driving ageing of the component tissues of the musculoskeletal system, both individually and as an integrated system? This will include the role of genetics and lifestyle; the role of inflammation, physical activity and changes in tissue steroid hormones; age-related loss of neuromuscular function and its contribution to reduced coordination, balance and reduced ability to perform complex motor tasks such as driving. 2. Assessment of interventions to improve musculoskeletal function in old age. It is well established that physical activity reduces the loss of muscle and bone mass with age. In young subjects dietary supplements can increase muscle mass, improve metabolism and reduce inflammation, but efficacy in older adults is largely unknown. The Centre will determine optimal exercise and nutritional supplementation regimes for musculoskeletal maintenance in older adults, both healthy and frail. Interventions will also include pharmacological approaches aimed at reducing inflammation and adjusting hormone balance in favour of musculoskeletal maintenance. 3. Identifying psychological and environmental (practical) barriers to increased physical activity or weight loss in older adults will be a key question addressed by the Centre, with the aim of developing interventions that will be practical and attractive to older adults.

衰老是一个复杂的过程，导致身体大部分器官系统功能下降，肌肉骨骼系统（肌肉、骨骼、肌腱和软骨）受到严重影响。肌肉骨骼系统不仅会随着年龄的增长而失去肌肉、骨骼和软骨，而且还会由于神经系统功能的下降而受到损害，从而导致对运动和平衡的控制能力下降。衰老也往往伴随着体重增加，这会对关节造成进一步的压力，并导致软骨和骨骼的侵蚀，增加患骨关节炎（OA）的机会。重要的是，衰老和肥胖都会降低身体活动水平，增加体内炎症水平，改变激素平衡，所有这些都会影响身体维持肌肉骨骼系统的能力。因此，增加身体活动和干预措施能够减少炎症并纠正与年龄和肥胖相关的激素变化，为延迟肌肉骨骼系统中与年龄相关的变化提供了一条前进的道路。目的：其目标是通过整合和扩大两所领先的中部地区大学伯明翰和诺丁汉及其相关的NHS医院信托基金的互补研究和研究生培训活动，建立一个肌肉骨骼老化研究卓越中心。该中心还将建立一个独特的技术设施，用于测量人体肌肉，肌腱和骨骼代谢，这将为英国研究界提供宝贵的资源。该中心的研究目标是了解衰老如何导致肌肉骨骼功能丧失，并利用这些知识进行干预，尽量减少与年龄相关的肌肉骨骼衰退和疾病。这些干预措施的主要重点是锻炼和饮食。临床获益：该中心进行的研究的潜在临床效益是显著的，因为与年龄相关的肌肉骨骼功能丧失具有重大临床后果，包括增加福尔斯和骨折（髋关节和腕关节）、OA和疼痛的风险。每年有三分之一的老年人跌倒，76，000名患者因此导致髋部骨折。髋部骨折与发病率增加、独立性丧失相关，髋部骨折的1年死亡率为22%。英国有600万人患有OA 1，这是一种痛苦的疾病，会降低工作能力，并对生活质量产生重大影响。肥胖会加重OA，目前除了疼痛治疗外，没有其他治疗方法。肌肉骨骼系统的组成组织老化的关键因素是什么，无论是单独的还是作为一个整体系统？这将包括遗传学和生活方式的作用;炎症，身体活动和组织类固醇激素变化的作用;与年龄相关的神经肌肉功能丧失及其对协调，平衡和执行复杂运动任务（如驾驶）能力降低的贡献。2.评估干预措施，以改善老年肌肉骨骼功能。众所周知，体力活动可以减少肌肉和骨量随年龄的损失。在年轻受试者中，膳食补充剂可以增加肌肉质量，改善新陈代谢和减少炎症，但在老年人中的疗效在很大程度上是未知的。该中心将确定最佳的运动和营养补充方案，以维持健康和虚弱的老年人的肌肉骨骼。干预措施还将包括旨在减少炎症和调整激素平衡以利于肌肉骨骼维护的药理学方法。3.确定心理和环境（实际）障碍，增加体力活动或减肥的老年人将是一个关键问题，由该中心解决，目的是制定干预措施，将是实际的和有吸引力的老年人。

项目成果

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

• DOI: 10.1210/clinem/dgac613
• 发表时间: 2023-03-10
• 期刊: The Journal of clinical endocrinology and metabolism

Association Between Corrected QT Interval and Inflammatory Cytokines in Rheumatoid Arthritis

• DOI: 10.3899/jrheum.140861
• 发表时间: 2015-03-01
• 期刊: JOURNAL OF RHEUMATOLOGY
• 影响因子: 3.9
• 作者: Adlan, Ahmed M.;Panoulas, Vasileios F.;Kitas, George D.
• 通讯作者: Kitas, George D.

Diagnostic outcomes associated with ankle synovitis in early inflammatory arthritis: a cohort study.

早期炎症性关节炎中与踝关节滑膜炎相关的诊断结果：一项队列研究。

• 发表时间: 2014
• 期刊: Clinical and experimental rheumatology
• 影响因子: 3.7
• 作者: Abhishek A

Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer.

• DOI: 10.1016/j.clnu.2021.09.040
• 发表时间: 2021-11
• 期刊: Clinical nutrition (Edinburgh, Scotland)
• 作者: Adiamah A;Rollins KE;Kapeleris A;Welch NT;Iftikhar SY;Allison SP;Lobo DN
• 通讯作者: Lobo DN

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

• DOI: 10.1111/acel.13202
• 发表时间: 2020-09
• 期刊: Aging cell
• 影响因子: 7.8
• 作者: Abdulla H;Phillips BE;Wilkinson DJ;Limb M;Jandova T;Bass JJ;Rankin D;Cegielski J;Sayda M;Crossland H;Williams JP;Smith K;Idris I;Atherton PJ
• 通讯作者: Atherton PJ