Centre for Musculoskeletal Ageing Research

研究背景：我们活得更长，但不健康，英国成年人平均在生命的最后十年健康状况不佳。我们的肌肉骨骼系统（肌肉，骨骼，软骨和肌腱）的衰退以及关节疾病，如骨关节炎（OA）和风湿性关节炎（RA），是老年健康状况不佳的主要原因。NHS每年因肌肉骨骼衰退而付出的代价超过50亿英镑。对目前的局势无所作为是一个昂贵和站不住脚的选择。肌肉骨骼老化研究中心旨在了解与年龄相关的肌肉骨骼功能丧失以及生活方式（缺乏运动和肥胖）在影响这一过程中所起的作用。体育活动和基于饮食的干预措施由该中心进行测试，以确保这些措施对老年人有效。该中心还包括动机心理学研究，以制定鼓励人们采取健康生活方式的方法。宗旨和目标：在中心的第二个5年，研究将扩大到调查导致一个人从健康的老年发展到患关节炎的过程。这将为预防和治疗关节炎开辟新的途径。增加对影响肌肉骨骼系统老化速度的过程的理解，以及这些过程如何增加对虚弱和疾病的易感性; 2.开发和测试干预措施，以改善肌肉骨骼健康; 3.发展强大的国家和国际网络，以建立一个重要的健康肌肉骨骼老龄化研究，培训和传播设施;增加现有患者队列和数据的使用，以支持我们的目标; 5.与关键的政策和健康实践影响者，行业和PPI团体合作，找到将我们的研究转化为健康益处的途径。潜在应用和益处：该中心开展的研究的潜在益处是显著的，因为与年龄相关的肌肉骨骼功能丧失会对健康产生重大影响，并降低继续就业和保持独立的能力。应用我们获得的知识来了解衰老与关节炎发展之间的联系，将进一步增加我们工作的影响，可能揭示预防或治疗关节炎的新途径。将我们的运动干预措施应用于已确诊疾病的患者，可以帮助减轻疼痛和疲劳，提高生活质量。对英国关节炎研究战略重点的贡献（2015 - 2020）。CMAR的研究将有助于英国关节炎研究的战略重点，帮助了解衰老和关节炎之间的联系，以及生活方式和药理学方法如何延迟前者以预防后者。例如，如果中心的研究表明，驱动正常衰老的过程也有助于关节炎的发展，那么一些正在测试的减缓衰老过程的新药也可能有助于预防关节炎的发展，使我们更接近治愈。研究运动对减轻OA或RA成人疼痛和疲劳的益处将改变患者的生活质量。因此，该中心的研究方案将有助于实现ARUK的"预防、改造、治疗"战略。本总结是在我们的关节炎PPI组R2P2中起草的。他们支持可以提供如何安全锻炼建议的研究，担心锻炼会使他们的疼痛或疾病恶化是常见的。他们支持任何可以延缓或预防疾病的治疗方法，特别是药物再利用。总的来说，他们是支持的，并认为这是有意义的，以扩大我们的计划对疾病的发病机制，并与其他中心合作，分享知识。至于参与计划的长者团体，他们建议支援中心的团体亦应包括健康的长者，所以我们会这样做

Research context: We are living longer but not healthier, with adults in the UK on average now spending the last decade of life in poor health. Decline in our musculoskeletal system (muscle, bone, cartilage and tendon), and diseases of the joints such as Osteoarthritis (OA) and Rheumatoid Arthritis (RA), are major contributors to ill health in old age. The annual cost to the NHS of musculoskeletal decline is over £5 billion. Doing nothing about the current situation is an expensive and untenable option. The Centre for Musculoskeletal Ageing Research aims to understand the age-related loss of musculoskeletal function and the role played by lifestyle (physical inactivity and obesity) in influencing this process. Physical activity and diet-based interventions are tested by the Centre to ensure these are effective in older adults. The Centre also includes motivational psychology research to develop approaches that encourage people to adopt healthy lifestyles. Aims and objectives:In the second 5 years of the Centre the research will expand to investigate the processes that cause a person to progress from healthy old age to developing arthritis. This will open up new ways to prevent and treat arthritis.The objectives of the Centre are:1. To increase understanding of the processes influencing the rate of ageing of the musculoskeletal system and how these increase susceptibility to frailty and disease; 2. To develop and test interventions to improve musculoskeletal health;3. To develop strong national and international networking to create a significant Healthy Musculoskeletal Ageing research, training and dissemination facility;4. To increase use of existing patient cohorts and data to support our aims;5. To work with key policy and health practice influencers, industry and PPI groups to find routes to translation of our research in to health benefits. Potential applications and benefits:The potential benefits of the research carried out by the Centre are significant as age-related loss of musculoskeletal function has major health consequences and reduced ability to stay in employment and maintain independence. Applying the knowledge we acquire to understanding the link between ageing and the development of arthritis will increase the impact of our work further, potentially revealing novel routes to the prevention or treatment of arthritis. Applying our exercise interventions to those with established disease can help reduce pain and fatigue and improve quality of life. Contribution to the Arthritis Research UK strategic focus (2015-2020).The research in CMAR will contribute to the strategic focus of Arthritis Research UK, helping to understand the link between ageing and arthritis and how lifestyle and pharmacological approaches can delay the former to prevent the latter. For example, if Centre research reveals that the processes that drive normal ageing also contribute to the development of arthritis, then some of the new drugs being tested to slow the ageing process may also help prevent development of arthritis, bringing us closer to a Cure. Work on the benefits of exercise for reducing pain and fatigue in adults with OA or RA will transform patient quality of Life. Together the Centre's research programme will thus help meet ARUK's "Prevent, Transform, Cure" strategy. This summary was drafted with patients in our arthritis PPI group R2P2. They were supportive of research that could give advice on how to exercise safely, fear of making their pain or disease worse with exercise was common. They were supportive of any treatments that could delay or prevent disease, especially drug repurposing. Overall they were supportive and thought it made sense to expand our programme toward disease pathogenesis and to work with other centres to share knowledge. On the subject of PPI group involvement, they suggested that the group supporting the Centre should include healthy elders too, so we will do this