Centre for Musculoskeletal Ageing Research

肌肉骨骼衰老研究中心

• 批准号: MR/P021220/1
• 负责人: Janet Lord
• 金额: $ 108.26万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP021220%2F1
• 关键词: Centre; Musculoskeletal; Ageing; Research

Research context: We are living longer but not healthier, with adults in the UK on average now spending the last decade of life in poor health. Decline in our musculoskeletal system (muscle, bone, cartilage and tendon), and diseases of the joints such as Osteoarthritis (OA) and Rheumatoid Arthritis (RA), are major contributors to ill health in old age. The annual cost to the NHS of musculoskeletal decline is over £5 billion. Doing nothing about the current situation is an expensive and untenable option. The Centre for Musculoskeletal Ageing Research aims to understand the age-related loss of musculoskeletal function and the role played by lifestyle (physical inactivity and obesity) in influencing this process. Physical activity and diet-based interventions are tested by the Centre to ensure these are effective in older adults. The Centre also includes motivational psychology research to develop approaches that encourage people to adopt healthy lifestyles. Aims and objectives:In the second 5 years of the Centre the research will expand to investigate the processes that cause a person to progress from healthy old age to developing arthritis. This will open up new ways to prevent and treat arthritis.The objectives of the Centre are:1. To increase understanding of the processes influencing the rate of ageing of the musculoskeletal system and how these increase susceptibility to frailty and disease; 2. To develop and test interventions to improve musculoskeletal health;3. To develop strong national and international networking to create a significant Healthy Musculoskeletal Ageing research, training and dissemination facility;4. To increase use of existing patient cohorts and data to support our aims;5. To work with key policy and health practice influencers, industry and PPI groups to find routes to translation of our research in to health benefits. Potential applications and benefits:The potential benefits of the research carried out by the Centre are significant as age-related loss of musculoskeletal function has major health consequences and reduced ability to stay in employment and maintain independence. Applying the knowledge we acquire to understanding the link between ageing and the development of arthritis will increase the impact of our work further, potentially revealing novel routes to the prevention or treatment of arthritis. Applying our exercise interventions to those with established disease can help reduce pain and fatigue and improve quality of life. Contribution to the Arthritis Research UK strategic focus (2015-2020).The research in CMAR will contribute to the strategic focus of Arthritis Research UK, helping to understand the link between ageing and arthritis and how lifestyle and pharmacological approaches can delay the former to prevent the latter. For example, if Centre research reveals that the processes that drive normal ageing also contribute to the development of arthritis, then some of the new drugs being tested to slow the ageing process may also help prevent development of arthritis, bringing us closer to a Cure. Work on the benefits of exercise for reducing pain and fatigue in adults with OA or RA will transform patient quality of Life. Together the Centre's research programme will thus help meet ARUK's "Prevent, Transform, Cure" strategy. This summary was drafted with patients in our arthritis PPI group R2P2. They were supportive of research that could give advice on how to exercise safely, fear of making their pain or disease worse with exercise was common. They were supportive of any treatments that could delay or prevent disease, especially drug repurposing. Overall they were supportive and thought it made sense to expand our programme toward disease pathogenesis and to work with other centres to share knowledge. On the subject of PPI group involvement, they suggested that the group supporting the Centre should include healthy elders too, so we will do this

研究背景：我们活得更长了，但并没有变得更健康，平均而言，英国成年人过去十年的健康状况不佳。我们的肌肉骨骼系统(肌肉、骨骼、软骨和肌腱)的衰退，以及关节疾病，如骨关节炎(OA)和类风湿性关节炎(RA)，是老年人健康状况不佳的主要原因。NHS每年因肌肉骨骼减少而造成的损失超过50亿GB。对当前局势无所作为是一个代价高昂且站不住脚的选择。肌肉骨骼老化研究中心旨在了解与年龄有关的肌肉骨骼功能丧失，以及生活方式(缺乏运动和肥胖)在影响这一过程中所起的作用。该中心测试了体力活动和以饮食为基础的干预措施，以确保这些措施对老年人有效。该中心还包括动机心理学研究，以开发鼓励人们采用健康生活方式的方法。目的和目标：在该中心的第二个五年中，这项研究将扩大到调查导致一个人从健康的老年发展到发展中的关节炎的过程。该中心的目标是：1.增加对影响肌肉骨骼系统衰老速度的过程的了解，以及这些过程如何增加对脆弱和疾病的易感性；2.开发和测试改善肌肉骨骼健康的干预措施；3.发展强大的国家和国际网络，以创建一个重要的健康肌肉骨骼老化研究、培训和传播设施；4.增加对现有患者队列和数据的使用，以支持我们的目标；5.与主要的政策和健康实践影响者、行业和PPI团体合作，找到将我们的研究转化为健康益处的途径。潜在的应用和好处：该中心进行的研究的潜在好处是巨大的，因为与年龄有关的肌肉骨骼功能丧失会对健康造成严重后果，并降低继续就业和保持独立的能力。应用我们获得的知识来理解衰老和关节炎发展之间的联系将进一步增加我们工作的影响，可能揭示预防或治疗关节炎的新途径。将我们的运动干预应用于那些已有疾病的人，可以帮助减轻疼痛和疲劳，提高生活质量。对英国关节炎研究的战略重点(2015-2020年)的贡献。Cmar的研究将有助于英国关节炎研究的战略重点，帮助了解衰老和关节炎之间的联系，以及生活方式和药理学方法如何推迟前者以预防后者。例如，如果中心的研究表明，推动正常衰老的过程也有助于关节炎的发展，那么正在测试的一些减缓衰老过程的新药也可能有助于防止关节炎的发展，使我们更接近治愈的方法。研究运动对减轻成人骨性关节炎或类风湿性关节炎患者疼痛和疲劳的益处，将改变患者的生活质量。因此，该中心的研究计划将有助于实现ARUK的“预防、转化、治疗”战略。这份摘要是与我们的关节炎PPI组R2P2中的患者一起起草的。他们支持可以就如何安全锻炼提供建议的研究，担心锻炼会加剧他们的疼痛或疾病是很常见的。他们支持任何可以延缓或预防疾病的治疗方法，特别是药物再利用。总体而言，他们表示支持，认为扩大我们的疾病发病机制方案并与其他中心合作分享知识是有意义的。关于PPI小组参与的问题，他们建议支持中心的小组也应该包括健康的老年人，所以我们将这样做

项目成果

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

• DOI: 10.1210/clinem/dgac613
• 发表时间: 2023-03-10
• 期刊: The Journal of clinical endocrinology and metabolism

Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer.

• DOI: 10.1016/j.clnu.2021.09.040
• 发表时间: 2021-11
• 期刊: Clinical nutrition (Edinburgh, Scotland)
• 作者: Adiamah A;Rollins KE;Kapeleris A;Welch NT;Iftikhar SY;Allison SP;Lobo DN
• 通讯作者: Lobo DN

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

• DOI: 10.1111/acel.13202
• 发表时间: 2020-09
• 期刊: Aging cell
• 影响因子: 7.8
• 作者: Abdulla H;Phillips BE;Wilkinson DJ;Limb M;Jandova T;Bass JJ;Rankin D;Cegielski J;Sayda M;Crossland H;Williams JP;Smith K;Idris I;Atherton PJ
• 通讯作者: Atherton PJ