MICA: Early thrombolytic intervention in acute stroke by imaging with Electrical Impedance Tomography

MICA：通过电阻抗断层扫描成像对急性中风进行早期溶栓干预

• 批准号: MR/K00767X/1
• 负责人: David Holder
• 金额: $ 100.03万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK00767X%2F1
• 关键词: MICA; Early; thrombolytic; intervention; acute

Electrical Impedance Tomography (EIT) is a novel medical imaging method in which tomographic "slice" images are rapidly produced using rings of electrodes placed around the body. It is safe, portable and inexpensive. The principal applicant's group has demonstrated that EIT can rapidly image functional brain activity in neurological conditions like stroke, epilepsy and normal activity in animal models and has developed systems which work well in head-shaped tanks. Thrombolytic "clot-busting" treatment is a new treatment for acute stroke which must be given within three hours, but its take-up has been restricted because it is essential to undertake imaging of the head before it can be administered. This is because a sudden onset of weakness or disability which appears as a stroke, can be due to insufficient blood to a part of the brain or else bleeding into the brain. The clot-dissolving agent cannot be given until imaging has been used to assess if a bleed has occurred, as it could make the bleeding much worse with catastrophic consequences. EIT has the potential to provide an inexpensive portable unit for use in ambulances or GP surgeries which would revolutionise administration of this drug in acute stroke by providing imaging at the point of contact. This could be relayed over the internet to a radiologist who could then give permission for a paramedic to give the drug in the ambulance or in a remote centre. The plan is to make three technical improvements in imaging and design of a helmet or headnet containing the contacts needed for accurate brain EIT and test these objectively in tanks, anaesthetised rats and human patient studies. The final outcome will be a new EIT system design optimised for imaging in acute stroke, with rigorous evaluation of its performance in about 30 patients.

电阻抗断层成像（EIT）是一种新型的医学成像方法，其中使用放置在身体周围的电极环快速产生断层“切片”图像。它安全、便携、便宜。主要申请人的小组已经证明，EIT可以快速成像神经系统状况下的功能性脑活动，如中风、癫痫和动物模型中的正常活动，并且已经开发出在头形罐中工作良好的系统。 溶栓“凝块破坏”治疗是一种新的治疗急性中风的方法，必须在三小时内给予，但它的使用受到限制，因为在使用前必须进行头部成像。这是因为突然发作的虚弱或残疾，表现为中风，可能是由于大脑的一部分血液不足或出血进入大脑。血栓溶解剂不能给予，直到成像已被用来评估是否发生出血，因为它可能使出血更严重的灾难性后果。EIT有可能提供一种廉价的便携式装置，用于救护车或GP手术，通过在接触点提供成像，这将彻底改变这种药物在急性卒中中的给药方式。这可以通过互联网传递给放射科医生，然后放射科医生可以允许护理人员在救护车或远程中心给药。 该计划是在成像和头盔或头罩的设计方面进行三项技术改进，其中包含精确大脑EIT所需的接触，并在坦克，麻醉大鼠和人类患者研究中客观地测试这些技术。最终的结果将是一种新的EIT系统设计，该系统针对急性卒中的成像进行了优化，并在约30名患者中对其性能进行了严格的评估。

项目成果

A Versatile and Reproducible Multi-Frequency Electrical Impedance Tomography System.

• DOI: 10.3390/s17020280
• 发表时间: 2017-01-31
• 期刊: Sensors (Basel, Switzerland)
• 作者: Avery J;Dowrick T;Faulkner M;Goren N;Holder D
• 通讯作者: Holder D

The factorization method for three dimensional electrical impedance tomography

• DOI: 10.1088/0266-5611/30/4/045005
• 发表时间: 2013-12
• 期刊: Inverse Problems
• 影响因子: 2.1
• 作者: N. Chaulet;S. Arridge;Timo Betcke;David Holder

A Parallel Solver for the Forward Problem in Electrical Impedance Tomography using DUNE FEM.

使用 DUNE FEM 求解电阻抗断层扫描中正向问题的并行求解器。

• 发表时间: 2013
• 期刊: XVth International Conference of Electrical Bioimpedance and XIVth conference on Electrical Impedance Tomography, Heiligenstadt, Germany, April, 2013
• 作者: Jehl Markus

A new 3D head shaped tank containing a human skull phantom construction for electrical impedance tomography

一种新型 3D 头形罐，包含用于电阻抗断层扫描的人体头骨模型结构

• 发表时间: 2013
• 期刊: XVth International Conference of Electrical Bioimpedance and XIVth conference on Electrical Impedance Tomography, Heiligenstadt, Germany, April, 2013.
• 作者: Doru T

Asymptotic analysis of the transmission eigenvalue problem for a Dirichlet obstacle coated by a thin layer of non-absorbing media

涂有薄层非吸收介质的狄利克雷障碍物传输特征值问题的渐近分析

• DOI: 10.1093/imamat/hxu045
• 发表时间: 2015
• 期刊: IMA Journal of Applied Mathematics
• 影响因子: 1.2
• 作者: Cakoni F