Translating gene-environment interaction from aetiology to personalised medicine for anxiety and depression.

将基因与环境的相互作用从病因学转化为焦虑和抑郁的个性化医学。

• 批准号: MR/K021281/2
• 负责人: Robert Keers
• 金额: $ 8.17万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FK021281%2F2
• 关键词: Translating; gene; environment; interaction; aetiology

Anxiety and depression are the most common of all mental illnesses affecting as many as one in five people at some point in their lives. They are also amongst the earliest to emerge, with the majority of adult cases of both disorders beginning in childhood or adolescence. Anxiety and depression are extremely costly for afflicted individuals and society as a whole resulting in reduced over-all educational level, increased usage of sick leave and benefits and increased risk of substance dependence and suicide.Cognitive Behavioural Therapy (CBT) has been shown to be a safe, effective treatment for both depression and anxiety in children and adults. Nevertheless, at least two in five patients do not respond to CBT and may need to switch to a different treatment such as medication. Finding predictors of response is extremely important as it will allow doctors to pick the right treatment for the right person from the start, cutting costs and speeding up their recovery.Recent research suggests that 'plasticity' genes might make some individuals more sensitive to their environment than others. These 'plasticity' genes may therefore be important predictors of response to CBT. Dr Robert Keers will test this proposition at the institute of Psychiatry in London and Emory University, Atlanta. Dr Keers will attempt to identify new plasticity genes using a novel twin based method and then test these genes as predictors of response to CBT in patients with anxiety and depression.

焦虑和抑郁是所有精神疾病中最常见的，影响多达五分之一的人在他们生命中的某个时刻。他们也是最早出现的，大多数成年病例都是从儿童或青春期开始的。焦虑和抑郁症对个人和整个社会来说都是极其昂贵的，导致整体教育水平下降，病假和福利的使用增加，物质依赖和自杀的风险增加。认知行为疗法（CBT）已被证明是一种安全，有效的治疗儿童和成人的抑郁和焦虑的方法。然而，至少五分之二的患者对CBT没有反应，可能需要改用其他治疗方法，如药物治疗。找到反应的预测因子是非常重要的，因为它可以让医生从一开始就为正确的人选择正确的治疗方法，降低成本并加快他们的康复。最近的研究表明，“可塑性”基因可能使一些人对环境比其他人更敏感。因此，这些“可塑性”基因可能是对CBT反应的重要预测因子。罗伯特·基尔斯博士将在伦敦的精神病学研究所和亚特兰大的埃默里大学检验这一命题。Keers博士将尝试使用一种新的基于双胞胎的方法来识别新的可塑性基因，然后测试这些基因作为焦虑和抑郁患者对CBT反应的预测因子。

项目成果

Polygenic Scores for Differential Susceptibility to Emotional Symptoms Predict Response to Cbt in Child Anxiety

对情绪症状的不同易感性的多基因评分可预测儿童焦虑中对 Cbt 的反应

• DOI: 10.1016/j.euroneuro.2016.09.606
• 发表时间: 2017
• 期刊: European Neuropsychopharmacology
• 影响因子: 5.6
• 作者: Eley T

Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders.

• DOI: 10.1192/bjp.bp.115.168229
• 发表时间: 2016-09
• 期刊: The British journal of psychiatry : the journal of mental science
• 作者: Coleman JR;Lester KJ;Keers R;Roberts S;Curtis C;Arendt K;Bögels S;Cooper P;Creswell C;Dalgleish T;Hartman CA;Heiervang ER;Hötzel K;Hudson JL;In-Albon T;Lavallee K;Lyneham HJ;Marin CE;Meiser-Stedman R;Morris T;Nauta MH;Rapee RM;Schneider S;Schneider SC;Silverman WK;Thastum M;Thirlwall K;Waite P;Wergeland GJ;Breen G;Eley TC
• 通讯作者: Eley TC

Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders.

• DOI: 10.1002/ajmg.b.32558
• 发表时间: 2017-10
• 期刊: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
• 作者: Coleman JRI;Lester KJ;Keers R;Munafò MR;Breen G;Eley TC
• 通讯作者: Eley TC

COMBINING GENETIC AND GENE EXPRESSION METHODS TO IDENTIFY BIOLOGICAL PREDICTORS OF RESPONSE TO COGNITIVE BEHAVIOURAL THERAPY FOR ANXIETY DISORDERS

结合遗传和基因表达方法来识别焦虑症认知行为疗法反应的生物预测因子

• 发表时间: 2017
• 期刊: EUROPEAN NEUROPSYCHOPHARMACOLOGY
• 影响因子: 5.6
• 作者: Coleman Jonathan

Paranoid Ideation and Violence: Meta-analysis of Individual Subject Data of 7 Population Surveys.

• DOI: 10.1093/schbul/sbw006
• 发表时间: 2016-07
• 期刊: Schizophrenia bulletin
• 影响因子: 6.6
• 作者: Coid JW;Ullrich S;Bebbington P;Fazel S;Keers R
• 通讯作者: Keers R