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COMPARISON OF METHODS FOR ESTIMATING GFR AND EFFECTIVE RENAL PLASMA FLOW

COMPARISON OF METHODS FOR ESTIMATING GFR AND EFFECTIVE RENAL PLASMA FLOW
估算 GFR 和有效肾血浆流量的方法比较
批准号：
5218399
负责人：
GARY R MATZKE
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218399
关键词：
blood flow measurement carbopolycyclic compound clinical research glomerular filtration rate human subject kidney circulation kidney function kidney pharmacology liver disorder liver function pharmacokinetics

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中文摘要
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英文摘要
The objective of this study is to test the hypothesis that PAH and Iothalamate administration via intravenous bolus (IVB) provides accurate estimates of effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) as compared with the standard method of continuous infusion (CI) administration. This method will then be used to evaluate the relationship between renal function and hepatic function in normal volunteers and patients with hepatic insufficiency.
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