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CHARACTERIZATION OF DRUG REMOVAL BY CONTINUOUS VENO-VENOUS RENAL REPLACEMENT

CHARACTERIZATION OF DRUG REMOVAL BY CONTINUOUS VENO-VENOUS RENAL REPLACEMENT
连续静脉-静脉肾替代药物清除的特征
批准号：
5218369
负责人：
GARY R MATZKE
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218369
关键词：
blood filtration chronic renal failure clearance rate clinical research diffusion hemodialysis hemodynamics human subject human therapy evaluation kidney circulation ultrafiltration

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中文摘要
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英文摘要
This study will evaluate the efficiency of removal of selected probe drugs from patients with end stage renal disease (ESRD) who are receiving continuous veno-venous renal replacement therapy by: (1)assessing the effect of blood flow rate on drug clearance, (2)assessing the effect of dialysate flow rate on drug clearance, (3)determining if drug removal is dependent on filter membrane composition, and (4)ascertaining the effect of protein binding on drug removal during diffusion and ultrafiltration.
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会议论文
Characterization of Glomerular and Tubular Function
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
PLASMA CLEARANCE METHOD ESTIMATING GFR & ERPF
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