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DETERMINATION OF NORNALMEFENE CONCENTRATIONS AFTER NALMEFENE DOSING

DETERMINATION OF NORNALMEFENE CONCENTRATIONS AFTER NALMEFENE DOSING
纳美芬给药后去甲美芬浓度的测定
批准号：
5218367
负责人：
GARY R MATZKE
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218367
关键词：
analog clinical research human subject liver disorder liver pharmacology naltrexone narcotic antagonists pharmacokinetics

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英文摘要
471 The objective of this study is to characterize the pharmacokinetic profile of nalmefene and its metabolite, nornalmefene, in hepatically impaired (mild, moderate, and severe) subjects and age, gender, and weight matched healthy controls. This study will also determine the influence of liver dysfunction on nalmefene protein binding, and evaluates the possible relationships between nalmefene disposition and the Pittsburgh cocktail, used as metabolic probes for specific drug metabolizing enzymes.
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Characterization of Glomerular and Tubular Function
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
PLASMA CLEARANCE METHOD ESTIMATING GFR & ERPF
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