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PHARMACOKINETICS OF METABOLIC PROBES IN PATIENTS WITH RENAL INSUFFICIENCY

PHARMACOKINETICS OF METABOLIC PROBES IN PATIENTS WITH RENAL INSUFFICIENCY
肾功能不全患者代谢探针的药代动力学
批准号：
5218365
负责人：
GARY R MATZKE
金额：
$0.0万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/5218365
关键词：
caffeine chronic renal failure clinical research dapsone debrisoquin drug metabolism human subject kidney disorder kidney function kidney pharmacology muscle relaxants pharmacokinetics phenytoin

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中文摘要
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英文摘要
Determine the effects of renal insufficiency on drug metabolism by investigating specific metabolic pathways using the 'Pittsburgh' five drug cocktail of caffeine, debrisoquine, mephenytoin, chlorzoxazone, and dapsone; alterations in fractional metabolic clearance of specific metabolic pathways will enable investigators to determine the usefulness of metabolic cocktails in patients with renal disease.
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会议论文
Characterization of Glomerular and Tubular Function
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
PLASMA CLEARANCE METHOD ESTIMATING GFR & ERPF
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