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CHARACTERIZATION OF THE CAPACITY LIMITED RENAL ELIMINATION OF FAMOTIDINE AND PAH

CHARACTERIZATION OF THE CAPACITY LIMITED RENAL ELIMINATION OF FAMOTIDINE AND PAH
法莫替丁和 PAH 的肾脏清除能力有限的特征
批准号：
6245675
负责人：
GARY R MATZKE
金额：
$1.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-18 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245675
关键词：
antiulcer drug contrast media glomerular filtration rate human subject kidney pharmacology p aminohippurate renal tubular transport

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中文摘要
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英文摘要
To develop a valid method for measuring the functional capacity of the anionic and cationic pathways for renal tubular secretion in normal volunteers. Famotidine and PAH will be used as the cationic and anionic transport markers, respectively. Iothalamate will be used as the measure of glomerular filtration rate (GFR) during the study. This pilot study will include determination of the renal tubular transport maximum (Smax), the plasma concentration at 50% of Smax (EC50) through a step-up infusion rate, & the ratio GLr/GFR for both compounds.
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Characterization of Glomerular and Tubular Function
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
ROLE OF P GLYCOPROTEIN IN CATIONIC RENAL TUBULAR SECRETION
PLASMA CLEARANCE METHOD ESTIMATING GFR & ERPF
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