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EFFECTS OF XENICAL ON LPL AND HTGL FOLLOWING A FAT RICH BREAKFAST

EFFECTS OF XENICAL ON LPL AND HTGL FOLLOWING A FAT RICH BREAKFAST
富含脂肪的早餐后赛尼可对 LPL 和 HTGL 的影响
批准号:
5218197
负责人:
Robert H Eckel
金额:
$0.0万
依托单位:
--
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) are enzymes located on the surface of capillary endothelia. These two lipases act to remove triglyceride from the ore of circulating lipoprotein particles to initiate remodeling into smaller, denser forms. Xenical is a drug which, taken orally, inhibits gastric and pancreatic lipase activity by binding irreversibly to these enzymes to decrease intestinal fat absorption. Xenical may inhibit systemic lipases such as LPL and HTGL as well as gastrointestinal lipases. This study will investigate the effect of xenical and/or its metabolites on plasma LPL and HTGL activities in the fasted state and during the postprandial period.
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2018 Kern Lipid Conference
  • 批准号:
    9610114
  • 项目类别:
  • 资助金额:
    $1.95万
  • 财政年份:
    2018
  • 负责人:
    Robert H Eckel
  • 依托单位:
2017 Kern Lipid Conference
  • 批准号:
    9396189
  • 项目类别:
  • 资助金额:
    $1.0万
  • 财政年份:
    2017
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  • 依托单位:
2015 Kern Lipid Conference
  • 批准号:
    8985457
  • 项目类别:
  • 资助金额:
    $1.0万
  • 财政年份:
    2015
  • 负责人:
    Robert H Eckel
  • 依托单位:
Obesity and Cardiovascular Disease: Opportunity for Post-Doctoral Training
  • 批准号:
    9293351
  • 项目类别:
  • 资助金额:
    $27.8万
  • 财政年份:
    2014
  • 负责人:
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  • 依托单位:
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