EFFECTS OF XENICAL ON LPL AND HTGL FOLLOWING A FAT RICH BREAKFAST

富含脂肪的早餐后赛尼可对 LPL 和 HTGL 的影响

• 批准号: 5218197
• 负责人: Robert H Eckel
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5218197
• 关键词: clinical research; dietary lipid; enzyme activity; enzyme inhibitors; human subject; lipoprotein lipase; nutrition related tag; triacylglycerol lipase

Lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) are enzymes located on the surface of capillary endothelia. These two lipases act to remove triglyceride from the ore of circulating lipoprotein particles to initiate remodeling into smaller, denser forms. Xenical is a drug which, taken orally, inhibits gastric and pancreatic lipase activity by binding irreversibly to these enzymes to decrease intestinal fat absorption. Xenical may inhibit systemic lipases such as LPL and HTGL as well as gastrointestinal lipases. This study will investigate the effect of xenical and/or its metabolites on plasma LPL and HTGL activities in the fasted state and during the postprandial period.

脂蛋白脂肪酶（LPL）和肝甘油三酯脂肪酶（HTGL）是 位于毛细血管内皮细胞表面的酶。这两种脂肪酶 从循环脂蛋白中清除甘油三酯 颗粒开始重塑成更小，更致密的形式。赛尼可群岛 一种口服抑制胃和胰脂肪酶的药物 活性通过不可逆地结合这些酶，以减少肠 脂肪吸收赛尼可可抑制全身脂肪酶，如LPL和HTGL 以及胃肠道脂肪酶。本研究将探讨 赛尼可及其代谢产物对血浆LPL和HTGL影响 在空腹状态和餐后期间的活动。