Centre for Ageing and Vitality

衰老与活力中心

• 批准号: MR/L016354/1
• 负责人: Doug Turnbull
• 金额: $ 323.18万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL016354%2F1
• 关键词: Centre; Ageing; Vitality

Promoting lifelong health is important because age is the greatest risk factor for a wide range of clinical diseases, from cancer to cardiovascular disease. This is particularly important because there are an increasing number of elderly people in Western societies, and these individuals often have multiple health problems. Therefore preventing age related disease is a priority. Ageing results from a gradual, lifelong accumulation of damage to our bodies. Crucially, we know that many of the mechanisms involved in the ageing process can be modified by lifestyle factors such as physical activity and nutrition. The LLHW Centre for Ageing and Vitality aims to link together studies which look at the way we age with studies exploring the effectiveness of lifestyle factors. We believe these studies will lead to new insights into how these interventions work and new ways to allow healthy ageing in the future. Our major research programmes looking at the way we age will focus on abnormalities that occur in the way we produce energy through mitochondria and on the way our bodies react to damaged tissues (called inflammation). The major lifestyle programmes are based on looking at the effect of physical activity, or the reduced level of physical activity, as we age. We will also look at how what we eat can change the ageing process, for example, why do overweight individuals develop more age related disease? To ensure we make as much progress as possible, the Centre will have five core activities that will be crucial for all of the different programmes of research. These core activities are:1. Developing models of ageing in mice so we can carefully study the effects of lifestyle interventions such as exercise and nutrition on different organs; 2. Collect and carefully store tissues from human subjects and mouse models to ensure that we can use these optimally for research; 3. Understand how the effects of physical activity and nutrition alter ageing tissues; 4. Deliver the best possible training to young scientists so that they will become future research leaders in lifelong health and wellbeing;5. Provide valuable information to the public about lifelong health in a way that they will find it helpful and informative. Influence decisions made locally, regionally and nationally to help improve lifelong health

促进终身健康很重要，因为年龄是从癌症到心血管疾病等一系列临床疾病的最大风险因素。这一点特别重要，因为西方社会的老年人越来越多，这些人往往有多种健康问题。因此，预防与年龄有关的疾病是一个优先事项。衰老是由于我们身体逐渐的、终生的损伤积累而造成的。至关重要的是，我们知道，衰老过程中涉及的许多机制可以通过生活方式因素（如体育活动和营养）来改变。LLHW老龄化和活力中心旨在将研究我们衰老方式的研究与探索生活方式因素有效性的研究联系起来。我们相信，这些研究将为这些干预措施的工作方式提供新的见解，并为未来的健康老龄化提供新的方法。我们的主要研究项目着眼于我们衰老的方式，重点是我们通过线粒体产生能量的方式发生的异常，以及我们的身体对受损组织（称为炎症）的反应方式。主要的生活方式方案是基于观察身体活动的影响，或者随着年龄的增长身体活动水平的降低。我们还将研究我们吃的东西如何改变衰老过程，例如，为什么超重的人会患上更多与年龄有关的疾病？为了确保我们取得尽可能多的进展，该中心将有五个核心活动，这将是至关重要的所有不同的研究计划。这些核心活动是：1。开发小鼠衰老模型，以便我们能够仔细研究生活方式干预（如运动和营养）对不同器官的影响; 2.收集并仔细储存来自人类受试者和小鼠模型的组织，以确保我们可以最佳地将其用于研究; 3.了解身体活动和营养的影响如何改变衰老的组织; 4.为年轻科学家提供最好的培训，使他们成为终身健康和福祉的未来研究领导者;5.向公众提供有关终身健康的有价值的信息，使他们觉得这些信息是有用的和翔实的。影响当地、区域和国家的决策，帮助改善终身健康

项目成果

The genetics and pathology of mitochondrial disease.

• DOI: 10.1002/path.4809
• 发表时间: 2017-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Alston, Charlotte L.;Rocha, Mariana C.;Lax, Nichola Z.;Turnbull, Doug M.;Taylor, Robert W.
• 通讯作者: Taylor, Robert W.

Systematic development of a theory-informed multifaceted behavioural intervention to increase physical activity of adults with type 2 diabetes in routine primary care: Movement as Medicine for Type 2 Diabetes.

• DOI: 10.1186/s13012-016-0459-6
• 发表时间: 2016-07-19
• 期刊: Implementation science : IS
• 作者: Avery L;Charman SJ;Taylor L;Flynn D;Mosely K;Speight J;Lievesley M;Taylor R;Sniehotta FF;Trenell MI
• 通讯作者: Trenell MI

Diagnosis and Treatment of Mitochondrial Myopathies.

• DOI: 10.1007/s13311-018-00674-4
• 发表时间: 2018-10
• 期刊: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
• 作者: Ahmed ST;Craven L;Russell OM;Turnbull DM;Vincent AE
• 通讯作者: Vincent AE

Using a quantitative quadruple immunofluorescent assay to diagnose isolated mitochondrial Complex I deficiency.

• DOI: 10.1038/s41598-017-14623-2
• 发表时间: 2017-11-15
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Ahmed ST;Alston CL;Hopton S;He L;Hargreaves IP;Falkous G;Oláhová M;McFarland R;Turnbull DM;Rocha MC;Taylor RW
• 通讯作者: Taylor RW