Developing insight into the molecular origins of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis

深入了解家族性和散发性额颞叶痴呆和肌萎缩侧索硬化症的分子起源

• 批准号: nhmrc : 1095215
• 负责人: A/Pr Ian Blair
• 金额: $ 446.1万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developing-insight-molecular-lateral-sclerosis/662354
• 关键词: Developing; insight; into; molecular; origins

There is strong evidence that frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) represent a spectrum of neurodegenerative disease with common origins. A combined study of FTD/ALS patient cohorts will provide greater power to identify these shared molecular origins. We aim to discover gene variants that cause, predispose, or modify onset and progression of inherited and sporadic FTD/ALS, and validate and study our discoveries in new cell and animal models of these disorders.

有强有力的证据表明，额颞叶痴呆（FTD）和肌萎缩侧索硬化症（ALS）代表了一系列具有共同起源的神经退行性疾病。FTD/ALS患者队列的联合研究将提供更大的把握度来确定这些共有的分子来源。我们的目标是发现导致，易感或改变遗传性和散发性FTD/ALS的发病和进展的基因变异，并验证和研究我们在这些疾病的新细胞和动物模型中的发现。