The role of mutant cyclin F in amyotrophic lateral sclerosis

突变细胞周期蛋白F在肌萎缩侧索硬化症中的作用

• 批准号: nhmrc : 1107644
• 负责人: A/Pr Ian Blair
• 金额: $ 69.46万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-mutant-cyclin-lateral-sclerosis/662992
• 关键词: role; mutant; cyclin; amyotrophic; lateral

Amyotrophic lateral sclerosis (ALS, also known as motor neuron disease, MND) is characterised by rapid paralysis leading to death within 2 to 5 years of onset. There are no effective diagnostic tests or treatments. Confusion remains around the primary cause of paralysis. We recently discovered ALS gene mutations that disrupt normal nerve function, a process known as abnormal protostasis. This gives us a unique opportunity to unlock the primary cause of paralysis and develop animal models of ALS

肌萎缩侧索硬化症(ALS，又称运动神经元病，MND)的特点是发病后2至5年内迅速瘫痪导致死亡。目前还没有有效的诊断测试或治疗方法。人们仍然对瘫痪的主要原因感到困惑。我们最近发现了ALS基因突变，这种突变会扰乱正常的神经功能，这一过程被称为异常原生状态。这给了我们一个独特的机会来解开瘫痪的主要原因并开发ALS的动物模型