Investigation of dysfunction of SIGMAR1 in transgenic mouse models, a novel gene implicated in neurodegeneration

转基因小鼠模型中 SIGMAR1 功能障碍的研究，SIGMAR1 是一种与神经退行性疾病有关的新基因

• 批准号: nhmrc : 1005769
• 负责人: A/Pr Ian Blair
• 金额: $ 32.81万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-dysfunction-sigmar1-implicated-neurodegeneration/109112
• 关键词: Investigation; dysfunction; SIGMAR1; transgenic; mouse

At present, there are no effective therapies for frontotemporal dementia or motor neuron disease. We have identified the SIGMAR1 gene as having a crucial role for these diseases. More importantly, there are therapeutically relevant small molecule drugs that are known to modulate the activity of this gene. We aim to determine the efficacy of pharmacological modulation of Sigma-1 receptor activity in mouse models of dementia.

目前，还没有对额颞叶痴呆或运动神经元病的有效治疗方法。我们已经确定SIGMAR1基因在这些疾病中起着至关重要的作用。更重要的是，已知有一些与治疗相关的小分子药物可以调节这种基因的活性。我们的目的是确定药物调节Sigma-1受体活性在痴呆小鼠模型中的有效性。