COCAINE EFFECTS ON REGIONAL CEREBRAL BLOOD FLOW--A PILOT O15 STUDY

可卡因对区域脑血流的影响——O15 试点研究

基本信息

  • 批准号:
    2353498
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
  • 资助国家:
    美国
  • 起止时间:
  • 项目状态:
    未结题

项目摘要

The trial is based on preliminary data showing that upright tilt table testing can provoke a drop in blood pressure consistent with neurally mediated hypotension (NMH) in a high proportion of those with chronic fatigue syndrome (CFS), and that unblinded treatment of the NMH leads to an improvement in CFS symptoms in 40-70% of CFS patients. The specific aim of this study is to determine whether patients aged 18-50 years with CFS and NMH will have a greater improvement in (1) self- reported general sense of well being and (2) objective orthostatic tolerance when treated with fludrocortisone than when treated with placebo. Eligible subjects are randomized to receive either fludrocortisone (escalating to 0.1 mg/day) or placebo for nine weeks. In week 8-9 of treatment, subjects undergo repeat tilt testing. The primary outcome measure is the proportion with a 15 point improvement in wellness on a 100 point wellness score, and a secondary outcome is the proportion with improvement in the number of minutes before the development of hypotension during upright tilt. The first patient was studied as part of this protocol March 4, 1996. From that date until November 30, 1996, we evaluated 70 patients with chronic fatigue syndrome. In 36 of these (54%), hypotension was documented during the first two stages of upright tilt testing. One patient with hypotension during the test had a wellness score that was above 70 at the time of the positive tilt test, and was therefore ineligible for participation. The remaining 35 subjects were randomized to fludrocortisone or placebo. Of these, 4 subjects have dropped out due to side effects. The study procedures appear to be well tolerated, and there have been no unanticipated problems with tilt testing or with the study medications. With very few exceptions, the study outcome data have been received in a timely manner by the company coordinating data entry. Of those enrolled, 25(71%) are female. All are Caucasian. These demographic characteristics reflect the epidemiologic patterns seen in other studies of CFS. Only one back individual has been evaluated for participation, but her tilt test was incomplete; no Hispanic, Asian or Pacific Islander, or American Indian or Alaskan Native has applied to the study.
试验是基于初步数据显示直立倾斜的桌子

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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其他文献

2022 Academy Member Benefits Update
  • DOI:
    10.1016/j.jand.2023.02.007
  • 发表时间:
    2023-04-01
  • 期刊:
  • 影响因子:
  • 作者:
  • 通讯作者:
Toward Social Hospital -snapshot of medical information technologies
走向社会医院——医疗信息技术快照
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    鈴木 真生; ;若尾 あすか;松村 耕平;野間 春生;Tomohiro Kuroda
  • 通讯作者:
    Tomohiro Kuroda
Structure and Magnetic Property of Spinel Ferrite Nanosheets Synthesized by Hydrothermal Method
水热法合成尖晶石铁氧体纳米片的结构与磁性能
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yuki Kamei ; Yuki Makinose ; Ken-ichi Katsumata ; ; NOBUHIRO MATSUSHITA
  • 通讯作者:
    NOBUHIRO MATSUSHITA
健康維持のための行動変容を働きかけるソーシャルシステムの開発
开发鼓励行为改变以保持健康的社会系统
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    鈴木 真生; ;若尾 あすか;松村 耕平;野間 春生
  • 通讯作者:
    野間 春生
微細加工による医療・創薬のためのバイオデバイス開発
通过微加工开发用于医疗和药物发现的生物设备
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yuki Kamei ; Yuki Makinose ; Ken-ichi Katsumata ; ; NOBUHIRO MATSUSHITA;H. Ago;一木隆範
  • 通讯作者:
    一木隆範

的其他文献

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{{ truncateString(' ', 18)}}的其他基金

CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - UNIVERSITY OF MINNESOTA FIELD CENTER.
年轻人冠状动脉风险发展 (CARDIA) 研究 - 明尼苏达大学实地中心。
  • 批准号:
    10901060
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
CORONARY ARTERY RISK DEVELOPMENT IN YOUNG ADULTS (CARDIA) STUDY - COORDINATING CENTER (CC)
年轻人冠状动脉风险发展 (CARDIA) 研究 - 协调中心 (CC)
  • 批准号:
    10901063
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Preclinical Services for Antibacterial Resistance Biopharmaceutical Product Development
抗菌药物耐药性生物制药产品开发的临床前服务
  • 批准号:
    10934774
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Preclinical Services for Biopharmaceutical Product Development
生物制药产品开发的临床前服务
  • 批准号:
    10934767
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
AWARD PINMED SBIR TOPIC #114 PHASE I
PINMED SBIR 主题奖
  • 批准号:
    10974171
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Pharmacology Consulting Services in relation to Pharmaceutical Development with Pain expertise. 09/12/2023 - 09/11/2024
与具有疼痛专业知识的药物开发相关的药理学咨询服务。
  • 批准号:
    10949065
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
FRAMINGHAM HEART STUDY - TASK AREA C - GENETIC RESULTS REPORTING
弗雷明汉心脏研究 - 任务领域 C - 基因结果报告
  • 批准号:
    10974185
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
FRAMINGHAM HEART STUDY - YEAR 5 EXAM
弗雷明汉心脏研究 - 五年级考试
  • 批准号:
    10953248
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Virtual Kick off Meeting with NCI for MAS Analysis Pool
与 NCI 举行 MAS 分析池虚拟启动会议
  • 批准号:
    10974493
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Preclinical Services for Biopharmaceutical Product Development
生物制药产品开发的临床前服务
  • 批准号:
    10934723
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:

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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
阿片类药物和可卡因滥用临床研究中心
  • 批准号:
    2695815
  • 财政年份:
    1986
  • 资助金额:
    --
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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
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  • 批准号:
    2116943
  • 财政年份:
    1986
  • 资助金额:
    --
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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
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  • 批准号:
    3105363
  • 财政年份:
    1986
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    --
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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
阿片类药物和可卡因滥用临床研究中心
  • 批准号:
    3105357
  • 财政年份:
    1986
  • 资助金额:
    --
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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
阿片类药物和可卡因滥用临床研究中心
  • 批准号:
    2012861
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    1986
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  • 批准号:
    2837847
  • 财政年份:
    1986
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    --
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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
阿片类药物和可卡因滥用临床研究中心
  • 批准号:
    3105362
  • 财政年份:
    1986
  • 资助金额:
    --
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CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
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    1986
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    --
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  • 批准号:
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    --
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