Developing synergisers of the antimalarial drug, chloroquine, for the treatment of chloroquine-resistant P. falciparum.
开发抗疟药氯喹的增效剂,用于治疗耐氯喹恶性疟原虫。
基本信息
- 批准号:nhmrc : 330402
- 负责人:
- 金额:$ 16.2万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2005
- 资助国家:澳大利亚
- 起止时间:2005-01-01 至 2007-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Malaria is a debilitating parasitic disease that is responsible for the deaths of about two million children each year. As drugs, such as chloroquine, become increasingly useless due to the development of parasite resistance, there is an urgent need to understand the mode of action of and the molecular basis of resistance to existing antimalarials and to design affordable treatments that can replace chloroquine. It is known that some compounds, that have only poor antimalarial activity themselves, can synergise the action of chloroquine. This may involve the inhibition of the activity of proteins that directly or indirectly extrude chloroquine from its site of action in the parasite's digestive apparatus. Unfortunately, thechloroquine synergisers examined to date have been too toxic to be useful in vivo. In preliminary studies we have identified some compounds that would be suitable for use in malaria patients, including a widely used antimalarial drug, primaquine, that can synergise the activity of chloroquine against chloroquine-resistant parasites. We will attempt to understand the molecular basis of this interaction. This will allow us to define optimal combinations of chloroquine and a resistance-reversing quinoline for use treating malaria. This could extend the clinical life of this important antimalarial drug. The information obtained may also help to design novel antimalarial drugs.
疟疾是一种使人衰弱的寄生虫病,每年造成约200万儿童死亡。由于寄生虫产生抗药性,氯喹等药物变得越来越无用,因此迫切需要了解现有抗疟药物的作用方式和抗药性的分子基础,并设计出能够取代氯喹的负担得起的治疗方法。已知一些本身抗疟活性很差的化合物可以协同氯喹的作用。这可能涉及抑制蛋白质的活性,这些蛋白质直接或间接地将氯喹从寄生虫消化器中的作用部位挤出。不幸的是,迄今为止研究的氯喹增效剂毒性太大,不能在体内使用。在初步研究中,我们已经确定了一些适合用于疟疾患者的化合物,包括一种广泛使用的抗疟药物伯氨喹,它可以协同氯喹对氯喹抗性寄生虫的活性。我们将试图了解这种相互作用的分子基础。这将使我们能够确定氯喹和逆转耐药性喹啉的最佳组合用于治疗疟疾。这可以延长这种重要抗疟疾药物的临床寿命。所获得的信息也可能有助于设计新的抗疟疾药物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Prof Leann Tilley其他文献
Prof Leann Tilley的其他文献
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{{ truncateString('Prof Leann Tilley', 18)}}的其他基金
Pushing the limits of fluorescence microscopy with adaptive optics
利用自适应光学器件突破荧光显微镜的极限
- 批准号:
LE180100001 - 财政年份:2018
- 资助金额:
$ 16.2万 - 项目类别:
Linkage Infrastructure, Equipment and Facilities
Bio-metrology and modelling of a complex system: the malaria parasite
复杂系统的生物计量学和建模:疟疾寄生虫
- 批准号:
FL150100106 - 财政年份:2016
- 资助金额:
$ 16.2万 - 项目类别:
Australian Laureate Fellowships
Proteasome inhibitors as reversers of resistance to artemisinin-based antimalarials
蛋白酶体抑制剂作为青蒿素类抗疟药耐药性的逆转剂
- 批准号:
nhmrc : 1092808 - 财政年份:2015
- 资助金额:
$ 16.2万 - 项目类别:
Development Grants
A cellular nano-imaging facility: Probing cellular complexity.
细胞纳米成像设施:探测细胞复杂性。
- 批准号:
LE120100037 - 财政年份:2012
- 资助金额:
$ 16.2万 - 项目类别:
Linkage Infrastructure, Equipment and Facilities
Probing sexual transformation of the human malaria parasite, Plasmodium falciparum, using novel imaging modalities
使用新型成像方式探索人类疟原虫恶性疟原虫的性转化
- 批准号:
DP110100624 - 财政年份:2011
- 资助金额:
$ 16.2万 - 项目类别:
Discovery Projects
Trafficking of the cytoadherence-mediating protein to the host cell surface in malaria parasite-infected erythrocytes
疟原虫感染的红细胞中细胞粘附介导蛋白转运至宿主细胞表面
- 批准号:
nhmrc : 433005 - 财政年份:2007
- 资助金额:
$ 16.2万 - 项目类别:
NHMRC Project Grants
ARC Centre of Excellence - Coherent X-ray Science
ARC 卓越中心 - 相干 X 射线科学
- 批准号:
CE0561787 - 财政年份:2005
- 资助金额:
$ 16.2万 - 项目类别:
ARC Centres of Excellence
Protein trafficking in malaria parasite-infected erythrocytes
疟原虫感染的红细胞中的蛋白质运输
- 批准号:
nhmrc : 280607 - 财政年份:2004
- 资助金额:
$ 16.2万 - 项目类别:
NHMRC Project Grants
Development of novel reagents for the point-of-care(field) diagnosis &differentiation of the malaria parasites, Plasmodi
开发用于现场诊断的新型试剂
- 批准号:
nhmrc : 280634 - 财政年份:2004
- 资助金额:
$ 16.2万 - 项目类别:
NHMRC Development Grants
Oxidative stress-induced alterations of the host erythrocyte by the malaria parasite
疟原虫氧化应激引起的宿主红细胞改变
- 批准号:
DP0450544 - 财政年份:2004
- 资助金额:
$ 16.2万 - 项目类别:
Discovery Projects