Oxidative stress-induced alterations of the host erythrocyte by the malaria parasite

疟原虫氧化应激引起的宿主红细胞改变

• 批准号: DP0450544
• 负责人: Prof Leann Tilley
• 金额: $ 37.43万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0450544
• 关键词: Oxidative; stress; induced; alterations; host

The malaria parasite spends part of its lifecycle inside the red blood cells of its host. During this time, the parasite modifies many of the features of the red blood cell and subjects it to high levels of oxidative stress. We will use and develop a variety of fluorescence and microscopic techniques to understand the molecular basis of the alterations in the organization of membrane proteins in malaria parasite-infected red blood cells. We will examine the roles of oxidative stress and of parasite proteins in modulating the properties of the host cell membrane.

疟疾寄生虫在其宿主的红细胞内度过其生命周期的一部分。在此期间，寄生虫改变了红细胞的许多特征，并使其受到高水平的氧化应激。我们将使用和开发各种荧光和显微镜技术，以了解疟原虫感染的红细胞膜蛋白组织变化的分子基础。我们将研究氧化应激和寄生虫蛋白在调节宿主细胞膜特性中的作用。