CLASSIFICATION OF EARLY ONSET DYSTHMIA

早发性心律失常的分类

• 批准号: 2745695
• 负责人: Daniel N Klein
• 金额: $ 28.03万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2745695
• 关键词: anxiety disorders; chronic disease /disorder; clinical depression; comorbidity; disease /disorder classification; human subject; interview; longitudinal human study; major depression; mental disorder diagnosis; pathologic process; personality disorders; social adjustment

DESCRIPTION (Adapted from Applican't Abstract): Dysthymic Disorder (DD) is a fairly prevalent condition with substantial social costs. As a nosological construct, it is defined and distinguished from Major Depressive Disorder (MDD) primarily on the bases of longitudinal course. Ironically, however, prospective data on the long-term course of DD are extremely limited. The present proposal seeks funding to complete the last five years of a then-year naturalistic follow-up study of DD, with follow-up evaluations being completed at 30 months intervals. Subjects include 97 outpatients who met DSM-III-R criteria for primary, early-onset dysthymia at entry into the study, and a comparison group of 45 outpatients with non-chronic (or episodic) major depression. Baseline and follow-up assessments include structured diagnostic interviews assessing Axis I and Axis II disorders conducted blind to the baseline evaluation, a comprehensive battery of self-report inventories, interviews with knowledgeable informants, and review of medical records. Attrition over the first five years of follow-up has been relatively low. The study addresses five major issues: (1) the diagnostic stability of DD; (2) the long-term naturalistic course of DD; (3) clinical, Psychosocial, and familial predictors of course and outcome; (4) the stability of comorbid anxiety and personality disorders, and their relationship with DD over time; and (5) the long-term course of social adjustment in DD.

描述(改编自《应用程序的摘要》)：恶劣心境障碍(DD)是一种相当普遍的疾病，具有巨大的社会成本。作为一个病因学概念，它主要是根据纵向病程来定义和区别于严重抑郁障碍(MDD)的。然而，具有讽刺意味的是，有关DD长期进程的预期数据极其有限。本提案寻求资金，以完成当时一年的自然发展战略后续研究的最后五年，并每隔30个月完成后续评估。受试者包括97名符合DSM-III-R标准的门诊患者和45名非慢性(或发作性)重度抑郁症患者。基线和后续评估包括对Axis I和Axis II障碍进行的结构化诊断访谈，对基线评估视而不见，一系列全面的自我报告清单，与知情人士的访谈，以及对医疗记录的审查。在最初五年的后续行动中，人员流失率相对较低。这项研究涉及五个主要问题：(1)发展迟缓的诊断稳定性；(2)发展迟缓的长期自然主义过程；(3)临床、心理社会和家庭因素对病程和结果的预测；(4)共病焦虑和人格障碍的稳定性及其与发展迟缓的关系；以及(5)发展迟缓的社会适应的长期过程。