RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSCLES

上呼吸道肌肉的呼吸相关运动输出

• 批准号: 6130534
• 负责人: SAMUEL T. KUNA
• 金额: $ 35.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-07-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6130534
• 关键词: afferent nerve; biomechanics; cats; decerebration; fiber optics; hypercapnia; larynx muscle; lung; motor neurons; muscle contraction; neuromuscular transmission; pharynxs; pulmonary respiration; respiratory airway volume; sensorimotor system; sensory feedback; tongue; trachea; vagus nerve

DESCRIPTION (Adapted from the Applicant's Abstract): The purpose of this proposal is to perform experiments in decerebrate cats to examine four specific aims: 1. To determine the neural input from the Kolliker-Fuse nucleus (KFN) to pharyngeal respiratory muscle motoneurons located in the hypoglossal nucleus (HGN). In addition, to neural pathways, neuromediator activity of the KLN will be explored. 2. To determine the effect of airway length on the mechanical effects of pharyngeal constrictor muscle contraction. It is hypoothesized that upper airway shortening may alter the mechanical effect of contraction of these muscles, such that they will have dilatory instead of constricting action. 3. To determine the effect of vagal afferent activity on pharyngeal muscle constrictor action. It is proposed that the pharyngeal muscles that are usually pharyngeal constrictors may become dilator muscles during hypercapnia in the absence of afferent vagal feedback. 4. To determine the changes in regional structure during contracture of various pharyngeal muscles by the use of retrograde fiberoptic imaging in a closed upper airway. This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania.

描述（改编自申请人摘要）：此目的