RESPIRATORY RELATED MOTOR OUTPUT TO UPPER AIRWAY MUSCLES

描述(改编自申请人的摘要)：本报告的目的 建议在去大脑的猫身上进行实验，以检查四种特定的 目的：1.确定Kolliker-Fuse核(KFN)的神经输入 位于舌下核的咽呼吸肌运动神经元 (HGN)。此外，对于神经通路，KLN的神经介质活性将 被探索。2.确定气道长度对机械性能的影响 咽缩肌收缩的影响。它被假设为 上呼吸道缩短可能改变这些收缩的机械效应。 肌肉，这样它们就会有伸展而不是收缩的动作。3. 测定迷走神经传入活动对咽肌的影响 毒蛇行动。据认为，咽部肌肉通常是 咽缩肌在高碳酸血症期间可能成为扩张肌 缺乏传入迷走神经反馈。4.确定地区和地区的变化 不同咽肌痉挛时的结构 在封闭的上呼吸道中进行逆行光纤成像。这项工作是一项 扩大该科迄今开展的工作，该科最近已迁至 宾夕法尼亚大学。

DESCRIPTION (Adapted from the Applicant's Abstract): The purpose of this proposal is to perform experiments in decerebrate cats to examine four specific aims: 1. To determine the neural input from the Kolliker-Fuse nucleus (KFN) to pharyngeal respiratory muscle motoneurons located in the hypoglossal nucleus (HGN). In addition, to neural pathways, neuromediator activity of the KLN will be explored. 2. To determine the effect of airway length on the mechanical effects of pharyngeal constrictor muscle contraction. It is hypoothesized that upper airway shortening may alter the mechanical effect of contraction of these muscles, such that they will have dilatory instead of constricting action. 3. To determine the effect of vagal afferent activity on pharyngeal muscle constrictor action. It is proposed that the pharyngeal muscles that are usually pharyngeal constrictors may become dilator muscles during hypercapnia in the absence of afferent vagal feedback. 4. To determine the changes in regional structure during contracture of various pharyngeal muscles by the use of retrograde fiberoptic imaging in a closed upper airway. This work is an expansion of work conducted to date by the PI, who has recently relocated to the University of Pennsylvania.