Diet-induced Arrangement of the gut Microbiome for improvement of Cardiometabolic health

饮食诱导的肠道微生物组排列可改善心脏代谢健康

• 批准号: MR/N030125/1
• 负责人: Tim Spector
• 金额: $ 21.38万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FN030125%2F1
• 关键词: Diet; induced; Arrangement; gut; Microbiome

The gut microbiota, that is, the communities of microorganisms in the human intestine, was recently recognized as an important factor influencing health throughout all stages of life. Obesity and type-2 diabetes have globally reached pandemic-like prevalence and are major risk factors for the development of cardiovascular diseases, in particular coronary artery disease and stroke. These pathologies are referred to as cardiometabolic diseases (CMD), and to effectively tackle them it is crucial to understand interplays between dietary and microbial factors that promote or inhibit transition from early metabolic symptoms to cardiovascular complications. CMD are associated with dysbiotic microbial ecosystems in the gut, or alterations in the composition and function of the microbiota. Diet is a prime influencing factor of both the intestinal milieu and risks for developing CMD, but knowledge about the reciprocal interaction between dietary components and microbial populations is scant. Moreover, although certain gut microbial metabolites have been implicated in the onset of CMD, molecular mechanisms are poorly characterized and causal relationships have yet to be determined. The DINAMIC consortium will bridge the gap by investigating interactions between diet and the gut microbiota, and the potential of modulating these interactions for prevention of metabolic dysfunction and cardiovascular complications in humans. This would enable novel nutritional strategies for prevention of CMD. The work programme is based on a combination of analysis of prospective and genetically well-characterized human cohorts to study associations between diet, the gut microbiome and cardiometabolic health parameters, with a series of targeted nutritional and microbiota intervention studies. The complementary use of large scale and targeted strategies, and explorative and interventional approaches, will deliver insights into nutritional strategies to develop practices for modulation of the intestinal microbiome to promote cardiometabolic health.

肠道微生物群，即人类肠道中的微生物群落，最近被认为是影响生命各个阶段健康的重要因素。肥胖和 2 型糖尿病在全球范围内已达到流行病的流行程度，是心血管疾病（特别是冠状动脉疾病和中风）发展的主要危险因素。这些病症被称为心脏代谢疾病（CMD），为了有效解决这些疾病，了解促进或抑制从早期代谢症状向心血管并发症转变的饮食和微生物因素之间的相互作用至关重要。 CMD 与肠道微生物生态系统失调或微生物群组成和功能的改变有关。饮食是肠道环境和 CMD 风险的主要影响因素，但有关饮食成分与微生物群之间相互作用的知识却很少。此外，尽管某些肠道微生物代谢物与 CMD 的发病有关，但分子机制尚不清楚，因果关系尚未确定。 DINAMIC 联盟将通过研究饮食与肠道微生物群之间的相互作用，以及调节这些相互作用以预防人类代谢功能障碍和心血管并发症的潜力，来弥合这一差距。这将为预防 CMD 提供新的营养策略。该工作计划基于对前瞻性和遗传特征良好的人类队列的分析，以研究饮食、肠道微生物组和心脏代谢健康参数之间的关联，并进行一系列有针对性的营养和微生物干预研究。大规模和有针对性的策略以及探索性和干预性方法的互补使用，将深入了解营养策略，以开发调节肠道微生物群的实践，以促进心脏代谢健康。

项目成果

Blue poo: impact of gut transit time on the gut microbiome using a novel marker.

• DOI: 10.1136/gutjnl-2020-323877
• 发表时间: 2021-09
• 期刊: Gut
• 影响因子: 24.5
• 作者: Asnicar F;Leeming ER;Dimidi E;Mazidi M;Franks PW;Al Khatib H;Valdes AM;Davies R;Bakker E;Francis L;Chan A;Gibson R;Hadjigeorgiou G;Wolf J;Spector TD;Segata N;Berry SE
• 通讯作者: Berry SE

Socioeconomic Status and the Gut Microbiome: A TwinsUK Cohort Study

• DOI: 10.3390/microorganisms7010017
• 发表时间: 2019-01-01
• 期刊: MICROORGANISMS
• 影响因子: 4.5
• 作者: Bowyer, Ruth C. E.;Jackson, Matthew A.;Steves, Claire J.
• 通讯作者: Steves, Claire J.

Genetic Determinants of the Gut Microbiome in UK Twins.

• DOI: 10.1016/j.chom.2016.04.017
• 发表时间: 2016-05-11
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: Goodrich JK;Davenport ER;Beaumont M;Jackson MA;Knight R;Ober C;Spector TD;Bell JT;Clark AG;Ley RE
• 通讯作者: Ley RE

Large-scale association analyses identify host factors influencing human gut microbiome composition.

• DOI: 10.1038/s41588-020-00763-1
• 发表时间: 2021-03
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Kurilshikov A;Medina-Gomez C;Bacigalupe R;Radjabzadeh D;Wang J;Demirkan A;Le Roy CI;Raygoza Garay JA;Finnicum CT;Liu X;Zhernakova DV;Bonder MJ;Hansen TH;Frost F;Rühlemann MC;Turpin W;Moon JY;Kim HN;Lüll K;Barkan E;Shah SA;Fornage M;Szopinska-Tokov J;Wallen ZD;Borisevich D;Agreus L;Andreasson A;Bang C;Bedrani L;Bell JT;Bisgaard H;Boehnke M;Boomsma DI;Burk RD;Claringbould A;Croitoru K;Davies GE;van Duijn CM;Duijts L;Falony G;Fu J;van der Graaf A;Hansen T;Homuth G;Hughes DA;Ijzerman RG;Jackson MA;Jaddoe VWV;Joossens M;Jørgensen T;Keszthelyi D;Knight R;Laakso M;Laudes M;Launer LJ;Lieb W;Lusis AJ;Masclee AAM;Moll HA;Mujagic Z;Qibin Q;Rothschild D;Shin H;Sørensen SJ;Steves CJ;Thorsen J;Timpson NJ;Tito RY;Vieira-Silva S;Völker U;Völzke H;Võsa U;Wade KH;Walter S;Watanabe K;Weiss S;Weiss FU;Weissbrod O;Westra HJ;Willemsen G;Payami H;Jonkers DMAE;Arias Vasquez A;de Geus EJC;Meyer KA;Stokholm J;Segal E;Org E;Wijmenga C;Kim HL;Kaplan RC;Spector TD;Uitterlinden AG;Rivadeneira F;Franke A;Lerch MM;Franke L;Sanna S;D'Amato M;Pedersen O;Paterson AD;Kraaij R;Raes J;Zhernakova A
• 通讯作者: Zhernakova A

Use of dietary indices to control for diet in human gut microbiota studies.

• DOI: 10.1186/s40168-018-0455-y
• 发表时间: 2018-04-25
• 期刊: Microbiome
• 影响因子: 15.5
• 作者: Bowyer RCE;Jackson MA;Pallister T;Skinner J;Spector TD;Welch AA;Steves CJ
• 通讯作者: Steves CJ