DENSE ARRAY EEG FOR STROKE LOCALIZATION

用于中风定位的密集阵列脑电图

• 批准号: 2873233
• 负责人: DON M TUCKER
• 金额: $ 11.67万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2873233
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain mapping; computer program /software; computer system design /evaluation; diagnosis design /evaluation; electroencephalography; human subject; image enhancement; stroke

DESCRIPTION: (Verbatim from the Applicant's Abstract) Stroke can now be treated. As new interventions are introduced for cerebral thrombosis and embolism, emergency stroke evaluation requires rapid assessment of ischemic brain damage Studies with both animal models and human neurosurgical monitoring have shown that the EEG provides an immediate reflection of cortical ischemia. In this Phase I project, we will determine the feasibility of acquiring dense array EEG with stroke patients in the hospital setting. We will then determine whether there is significant improvement in stroke localization with the 128-channel EEG compared to conventional 19-channel EEG. Localization of the ischemic lesion is integral to detecting a stroke with the EEG, because focal slowing can be differentiated from diffuse slowing due to other cerebral pathology. Even with advanced methods, EEG localization of a completed infarction will be inferior to that from MRI. Furthermore, CT may continue to be required for detecting hemorrhagic stroke. However, if we can improve localization with dense array EEG methods, we can improve the emergency detection of stroke, and thus optimize the excellent temporal resolution of the EEG in characterizing the dynamic time course of the pathophysiology of ongoing cerebral ischemia. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：(逐字摘自申请者摘要)中风现在可以 治疗过了。随着对脑血栓和脑血栓的新干预措施的推出 栓塞症、中风急诊评估需要快速评估缺血性 动物模型和人类神经外科监护下的脑损伤研究 研究表明，脑电可以立即反映大脑皮质的缺血情况。 在这个第一阶段的项目中，我们将确定获得密集的可行性 在医院环境中对中风患者进行脑电阵列。然后我们将确定 是否在卒中定位方面有显著的改善 128导联脑电与常规19导联脑电的比较。的本地化 缺血性损害是脑电检测中风不可或缺的一部分，因为局灶性 减慢可与其他大脑原因引起的弥漫性减慢区分开来 病理学。即使有了先进的方法，脑电定位也完成了 脑梗塞的程度将低于核磁共振。此外，CT可能会继续 是检测出血性中风所必需的。然而，如果我们能够改进 利用密集阵列脑电方法进行定位，可以提高急诊率 检测中风，从而优化优秀的时间分辨率的 脑电在刻画进行性脑损伤病理生理动态时间过程中的作用 脑缺血。 建议的商业应用：不可用