Dense Array EEG for Neonatal Sleep Monitoring

用于新生儿睡眠监测的密集阵列脑电图

• 批准号: 7120172
• 负责人: DON M TUCKER
• 金额: $ 36.35万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120172
• 关键词: arousal; bioimaging /biomedical imaging; biomedical equipment development; clinical research; electrodes; electroencephalography; human data; hypoxia neonatorum; miniature biomedical equipment; neurophysiology; patient monitoring device; polysomnography

DESCRIPTION (PROVIDED BY APPLICANT): Electroencephalography (EEG) is a safe, noninvasive technique for monitoring neonatal brain function. Acute and long-term EEG monitoring of infants has clinical utility for evaluating the effects of hypoxic ischemic insults and detecting the presence of epileptic activity. Medical intervention may be effective for several neonatal brain pathologies if these are detected early. In Sudden Infant Death Syndrome (SIDS), for example, disorders in the neurophysiology of sleep regulation may be potentially life-threatening for many infants, and may be amenable to treatment, but we have a limited understanding of both the normal neonatal sleep neurophysiology and its disregulation. The information available in neonatal EEG can be greatly enhanced by using an adequate number of electrodes to accurately map the spatial distribution of the EEG without spatial aliasing. The Geodesic EEG Neonatal Brain Monitor will be designed from experimental studies and theoretical simulations of the required sampling density for scalp potentials on the infant head. Dense Array EEG methods will be developed that incorporate the unique features of infant skull anatomy to estimate the potentials in the brain of the infant. The Geodesic EEG Neonatal Brain Monitor will be adapted for a variety of clinical uses, initially focusing on monitoring brain function in sleep in the Neonatal Intensive Care Unit (NICU). A low-cost product line would result from the Phase II work, ranging from simple 4- channel EEG with vital signs monitors to a 256-channel dense array system. These products will bring major advances to monitoring both normal and pathological brain states of the neonate, providing information on the maturation of arousal control and sleep in preterm and full term infants that may be important in understanding a variety of clinical disorders.

描述（申请人提供）：脑电图（EEG）是一种安全、无创的新生儿脑功能监测技术。婴儿的急性和长期EEG监测对于评估缺氧缺血性损伤的影响和检测癫痫活动的存在具有临床实用性。医疗干预可能是有效的几个新生儿脑部病变，如果这些被发现的早期。例如，在婴儿猝死综合征（SIDS）中，睡眠调节的神经生理学障碍可能对许多婴儿有潜在的生命威胁，并且可能适合治疗，但我们对正常新生儿睡眠神经生理学及其失调的理解有限。通过使用足够数量的电极来准确地映射EEG的空间分布而没有空间混叠，可以大大增强新生儿EEG中可用的信息。测地线EEG新生儿脑监测器将根据婴儿头部头皮电位所需采样密度的实验研究和理论模拟进行设计。将开发密集阵列EEG方法，该方法结合婴儿头骨解剖学的独特特征，以估计婴儿大脑中的电位。Geodesic EEG新生儿脑监测仪将适用于各种临床用途，最初侧重于监测新生儿重症监护室（NICU）睡眠中的脑功能。第二阶段的工作将产生一个低成本的产品线，从简单的4通道脑电图与生命体征监测器到256通道密集阵列系统。这些产品将为监测新生儿的正常和病理性大脑状态带来重大进展，提供有关早产儿和足月儿觉醒控制和睡眠成熟的信息，这对于了解各种临床疾病可能很重要。