Dense Array EEG for Neonatal Sleep Monitoring

用于新生儿睡眠监测的密集阵列脑电图

• 批准号: 6486287
• 负责人: DON M TUCKER
• 金额: $ 10.8万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2002-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6486287
• 关键词: arousal; bioimaging /biomedical imaging; biomedical equipment development; clinical research; electrodes; electroencephalography; human data; hypoxia neonatorum; miniature biomedical equipment; neurophysiology; patient monitoring device; polysomnography

DESCRIPTION (provided by applicant): Electroencephalography is a safe, noninvasive technique for monitoring neonatal brain function. Acute and long-term EEG monitoring of infants has clinical utility for evaluating the effects of hypoxic ischemic insults and detecting the presence of epileptic activity. The information available in neonatal EEG can be greatly enhanced by using an adequate number of electrodes to accurately map the spatial distribution of the EEG without spatial aliasing. The Geodesic Neonatal EEG Brain Monitor will be designed from experimental studies and theoretical simulations of the required sampling density for scalp potentials on the infant head. Dense Array EEG methods will be developed that incorporate the unique features of infant skull anatomy to estimate the potentials in the brain of the infant. The Geodesic Neonatal EEG Brain Monitor system will be adapted for a variety of clinical uses, initially focusing on monitoring brain function in sleep in the Neonatal Intensive Care Unit (NICU). This monitoring will examine both normal and pathological sleep states of the neonate, providing information on the maturation of arousal control in preterm and full term infants that may be important in understanding sudden infant death syndrome. PROPOSED COMMERCIAL APPLICATION: Behavioral outcome studies indicate that brain function is often at risk in the neonatal intensive care unit. An inexpensive, high-resolution neonatal brain state monitor could guide medical management to support brain health and therefore improve neurological and psychological outcome in many infants.

描述（由申请人提供）：脑电图是一种安全， 非侵入性技术监测新生儿脑功能。急性和 婴儿的长期脑电监测对于评估婴儿的脑功能具有临床实用性。 缺氧缺血性损伤的影响和检测癫痫的存在 活动新生儿EEG中可用的信息可以通过以下方法大大增强： 使用足够数量的电极来准确地绘制空间图 没有空间混叠的EEG分布。测地线新生儿脑电图 脑监测器将从实验研究和理论设计 婴儿头皮电位所需采样密度的模拟 头密集阵列EEG方法将被开发， 婴儿颅骨解剖学特征，以估计 婴儿。Geodesic新生儿EEG脑监测系统将适用于 各种临床用途，最初侧重于监测大脑功能， 新生儿重症监护室（NICU）本次监测将检查 新生儿的正常和病理睡眠状态，提供信息 对早产儿和足月儿觉醒控制的成熟， 对了解婴儿猝死综合症很重要。 拟定商业应用： 行为结果研究表明，新生儿的脑功能往往处于危险之中， 加护病房 一种廉价的、高分辨率的新生儿大脑状态监测器可以 指导医疗管理，以支持大脑健康，从而改善神经系统 和心理上的影响。