DENSE ARRAY EEG FOR STROKE LOCALIZATION

用于中风定位的密集阵列脑电图

• 批准号: 6394154
• 负责人: DON M TUCKER
• 金额: $ 53.54万
• 依托单位: ELECTRICAL GEODESICS, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394154
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain mapping; computer program /software; computer system design /evaluation; diagnosis design /evaluation; electroencephalography; human subject; image enhancement; stroke

DESCRIPTION: (Verbatim from the Applicant's Abstract) Stroke can now be treated. As new interventions are introduced for cerebral thrombosis and embolism, emergency stroke evaluation requires rapid assessment of ischemic brain damage Studies with both animal models and human neurosurgical monitoring have shown that the EEG provides an immediate reflection of cortical ischemia. In this Phase I project, we will determine the feasibility of acquiring dense array EEG with stroke patients in the hospital setting. We will then determine whether there is significant improvement in stroke localization with the 128-channel EEG compared to conventional 19-channel EEG. Localization of the ischemic lesion is integral to detecting a stroke with the EEG, because focal slowing can be differentiated from diffuse slowing due to other cerebral pathology. Even with advanced methods, EEG localization of a completed infarction will be inferior to that from MRI. Furthermore, CT may continue to be required for detecting hemorrhagic stroke. However, if we can improve localization with dense array EEG methods, we can improve the emergency detection of stroke, and thus optimize the excellent temporal resolution of the EEG in characterizing the dynamic time course of the pathophysiology of ongoing cerebral ischemia. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：（逐字来自申请人的摘要）中风现在可以是 治疗。随着新的干预措施被引入脑血栓形成， 栓塞，紧急卒中评估需要快速评估缺血性 脑损伤动物模型和人类神经外科监测研究 已经表明EEG提供了皮层缺血的即时反映。 在这个第一阶段的项目中，我们将确定获得密集的 阵列脑电图与中风患者在医院设置。然后我们将决定 是否有显着改善中风定位与 128-与传统的19通道EEG相比，定位 缺血性病变是用EEG检测中风不可或缺的，因为局灶性 可以区分由于其他脑血管疾病引起的弥漫性减慢。 病理即使有先进的方法，脑电定位的一个完整的 梗死的诊断结果低于MRI。此外，CT可以继续 用于检测出血性中风。但是，如果我们能够改善 定位与密集阵列脑电的方法，我们可以提高紧急 检测笔划，从而优化优秀的时间分辨率的 EEG在表征持续性脑梗死病理生理学动态时程中的作用 脑缺血 拟议商业应用：不可用