CHRONIC TRANSCRANIAL ELECTRICAL CONNECTOR
慢性经颅电连接器
基本信息
- 批准号:6016664
- 负责人:
- 金额:$ 48.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-15 至 2001-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The device described in this proposal addresses the need identified for high-density percutaneous feedthroughs and implantable electrical connectors for neural prosthesis. The goal is to develop a chronic system for the transcranial delivery of signals from high density, multichannel electrode arrays implanted in mammalian sensory and motor cortexes. In Phase I, a hermetic multi-layer ceramic package, capable of being mounted on top of the skull to house VLSI circuitry, was developed and demonstrated. Phase II will make minor design changes to the package and convert the metal flanges and braze to biocompatible materials such as titanium and gold braze. A polymide and/or Parylene microribbon cable (25 mum spacing, 15 mum thick) and a method of bonding it to the back of the microelectrode array and to the base of the ceramic package will be developed. A VLSI chip will be designed and manufactured that has up to 100 channels of pre-amplification, a high speed multiplexer, and an A/D converter. The final assembly of array, microribbon cable, ceramic package and VLSI chip will be tested in vitro and in vivo (cat auditory cortex for about three months). PROPOSED COMMERCIAL APPLICATION: The chronic transcranial electrical connector will be marketed to neuroscience researchers to enable them to use multielectrode arrays in chronic investigators of the parallel processing of the mammalian brain. The ceramic will also provide them with a platform on which to develop circuitry for human neuroprosthetics.
该提案中描述的设备满足了对神经假体的高密度经皮馈通和可植入电连接器的需求。目标是开发一种慢性系统,用于从植入哺乳动物感觉和运动皮层的高密度、多通道电极阵列经颅传输信号。在第一阶段,开发并演示了一种密封的多层陶瓷封装,能够安装在头骨顶部以容纳 VLSI 电路。第二阶段将对封装进行较小的设计更改,并将金属法兰和钎料转换为生物相容性材料,例如钛和金钎料。将开发聚酰亚胺和/或聚对二甲苯微带电缆(25μm间距,15μm厚)以及将其粘合到微电极阵列背面和陶瓷封装底部的方法。将设计和制造具有多达100个通道的前置放大、高速多路复用器和A/D转换器的VLSI芯片。阵列、微带电缆、陶瓷封装和VLSI芯片的最终组装将在体外和体内进行测试(猫听觉皮层约三个月)。拟议的商业应用:慢性经颅电连接器将销售给神经科学研究人员,使他们能够在哺乳动物大脑并行处理的长期研究人员中使用多电极阵列。这种陶瓷还将为他们提供一个开发人类神经假体电路的平台。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRIAN W HATT其他文献
BRIAN W HATT的其他文献
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{{ truncateString('BRIAN W HATT', 18)}}的其他基金
CHRONIC RAT SYSTEM FOR ELECTROPHYSIOLOGIC STUDY OF AGING
用于衰老电生理研究的慢性大鼠系统
- 批准号:
6335609 - 财政年份:2001
- 资助金额:
$ 48.31万 - 项目类别:
MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS
用于嗅觉研究的多电极阵列
- 批准号:
6681823 - 财政年份:1999
- 资助金额:
$ 48.31万 - 项目类别:
MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS
用于嗅觉研究的多电极阵列
- 批准号:
6021785 - 财政年份:1999
- 资助金额:
$ 48.31万 - 项目类别:
MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS
用于嗅觉研究的多电极阵列
- 批准号:
6516230 - 财政年份:1999
- 资助金额:
$ 48.31万 - 项目类别:
AFFORDABLE MULTICHANNEL DATA ACQUISITION SYSTEM
经济实惠的多通道数据采集系统
- 批准号:
6165183 - 财政年份:1999
- 资助金额:
$ 48.31万 - 项目类别:
AFFORDABLE MULTICHANNEL DATA ACQUISITION SYSTEM
经济实惠的多通道数据采集系统
- 批准号:
2878927 - 财政年份:1999
- 资助金额:
$ 48.31万 - 项目类别:
MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS
用于嗅觉研究的多电极阵列
- 批准号:
6292738 - 财政年份:1999
- 资助金额:
$ 48.31万 - 项目类别:
AFFORDABLE MULTICHANNEL DATA ACQUISITION SYSTEM
经济实惠的多通道数据采集系统
- 批准号:
2423299 - 财政年份:1997
- 资助金额:
$ 48.31万 - 项目类别: