CHRONIC RAT SYSTEM FOR ELECTROPHYSIOLOGIC STUDY OF AGING

用于衰老电生理研究的慢性大鼠系统

• 批准号: 6335609
• 负责人: BRIAN W HATT
• 金额: $ 10.5万
• 依托单位: BIONIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6335609
• 关键词: aging; biomaterial compatibility; biomedical equipment development; brain electrical activity; electrophysiology; hippocampus; laboratory rat; longitudinal animal study; microelectrodes; neural information processing; neurophysiology

DESCRIPTION (Adapted from applicant's abstract): A chronic rat system will be developed suitable for electrophysiological investigations of the aging brain, It will have an array of microelectrodes whose lengths are adjustable during manufacture so that the 3-D distribution of the electrode tips can be arranged to match the 3-D architecture of the cortical feature under study. This system will offer a unique opportunity to investigate in behaving rats the effect of aging on cortical information processing in a way not possible with current techniques. In addition to benefiting directly the aging research community, the tools and techniques resulting from Phases I and II will be applicable to many other programs using electrophysiological recordings from awake, behaving rats. Phase I develops the two key components: (1) a technique for making a 0.4-mm pitch microelectrode array structure where the lengths of individual electrodes can be between 0.5mm and 3.0mm, and (2) a 25-channel percutaneous connector. Chronic experiments will verify the biocompatibility of the connector and its fixation technique. Acute experiments will verify that the multielectrode array can record spontaneous neural activity in rat hippocampus. Phase II will optimize and validate the chronic system for implantation in rat hippocampus and demonstrate the relevance of electrophysiological findings in rat hippocampus to the aging process. PROPOSED COMMERCIAL APPLICATION: A chronic microelectrode array system will be marketed that is suitable for implantation in rats to study the electrophysiologic aspects of aging. It will also be marketed to researchers for investigating other cortical processes in rats.

描述（改编自申请人的摘要）： 将开发适合电生理学的慢性大鼠系统 对衰老大脑的研究，它将有一系列微电极 其长度在制造过程中可调节，以便 3-D 分布 电极尖端可以排列以匹配 3D 架构 正在研究的皮质特征。该系统将提供一个独特的机会 研究行为大鼠的衰老对皮质信息的影响 以当前技术不可能的方式进行处理。此外 直接使老龄化研究界、工具和技术受益 第一阶段和第二阶段的结果将适用于许多其他使用 清醒、有行为的老鼠的电生理记录。 第一阶段开发两个关键组件：(1) 制造 0.4 毫米的技术 节距微电极阵列结构，其中各个电极的长度 可以在 0.5mm 和 3.0mm 之间，以及 (2) 25 通道经皮连接器。 长期实验将验证连接器及其生物相容性 固定技术。急性实验将验证多电极阵列 可以记录大鼠海马体的自发神经活动。 第二阶段将优化和验证大鼠植入的慢性系统 海马体并证明电生理学发现的相关性 大鼠海马体的衰老过程。 拟议的商业应用： 适合植入的慢性微电极阵列系统将上市 在大鼠中研究衰老的电生理方面。 也将推向市场 研究人员研究大鼠的其他皮质过程。