AFFORDABLE MULTICHANNEL DATA ACQUISITION SYSTEM

该提案解决了NIMH确定的创新需求 可持续采集、分析和存储的计算机接口 供研究和临床使用的神经生理学数据。我们将发展 负担得起的数据采集硬件和软件将允许 多通道神经反应的并行记录、显示和分析 使用基于奔腾的PC系统。重点介绍与配合使用的系统 用于急慢性动物的多达100个皮质内电极阵列 调查。 硬件系统将： I)放大100个通道的神经数据， Ii)获取并存储超阈值动作电位的次数 波形或单元标识(第二阶段)。 这些软件工具将： I)控制数据采集过程； Ii)显示多单位尖峰活动，以及 3)显示三维神经活动(两个空间维度和一个时间维度)。 数据文件结构应适合导入第三方数据 分析软件。系统将使用合成数据进行验证并在 视觉刺激网络表征的生理学研究 在猫V1，以及药物对自发活动和连接性的影响 猫科动物感觉皮质中神经元的数量。 建议的商业应用： 负担得起的数据采集系统将使神经科学 研究人员将多电极阵列用于切片工作并长期 植入灵长类动物、猫科动物和啮齿动物模型的神经系统 调查与以下各项相关的并行处理和连接 精神功能正常或异常的精神功能。该系统还可以用于开发 治疗药物；并研究这两种疾病的潜在机制 滥用药物对神经系统的影响，以及获得性和 失忆。

This proposal addresses the need identified by the NIMH for innovative computer interfaces that can continuously acquire, analyze and store neurophysiological data for research and clinical use. We will develop affordable data acquisition hardware and software that will permit parallel recording, display, and analysis of multichannel neural responses with a Pentium-based PC system. The focus is on systems for use with arrays of up to 100 intracortical electrodes for acute and chronic animal investigations. The hardware systems will: i) amplify 100 channels of neural data, ii) acquire and store the times of super-threshold action potential waveforms or the unit identifiers(Phase II). The software tools will: i) control data acquisition processes, ii) display multi-unit spike activity, and iii) display 3-D neural activity (two spatial and one time dimension). Data file structure will be suitable for importing into third party data analysis software. Systems will be validated with synthesized data and in physiological investigations of network representations of visual stimuli in feline Vl, and drug effects on spontaneous activity and connectivities of neurons in feline sensory cortex. PROPOSED COMMERCIAL APPLICATION: The affordable data acquisition system will enable neuroscience researchers to use multielectrode arrays in 'slice' work and chronically implanted in the nervous systems of primates, felines, and rodent models to investigate the parallel processing and connectivities associated with normal or aberrant mental function. The system can also be used to develop therapeutic drugs; and to study the underlying mechanism both of the effect of drugs of abuse on the nervous system, and of the acquisition and loss of memory.