MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS

用于嗅觉研究的多电极阵列

• 批准号: 6516230
• 负责人: BRIAN W HATT
• 金额: $ 17.45万
• 依托单位: BIONIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2002-08-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516230
• 关键词: biomedical equipment development; biosensor device; brain electrical activity; computational neuroscience; electronic recording system; implant; laboratory rat; microelectrodes; olfactions; olfactory lobe; olfactory stimulus; sheep

DESCRIPTION(adapted from applicant's abstract): Of all human sensory modalities, those involving chemical detection (i.e. taste and smell), remain the least understood. Although a number of recent reports have been exciting in that they use various imaging modalities to investigate the spatial organization of olfactory bulb, there are currently no tools with which to simultaneously investigate the fine temporal and spatial structure of neural ensembles in the olfactory bulb. In Phase I, Bionic Technologies, Inc (BTI) successfully demonstrated the application of a microelectrode array to investigations of sensory processing in rat olfactory bulb. Building on these results, Phase II proposes to address several key issues in the deployment of this technology by the neuroscience community. In a unique collaboration with neuroscientists, BTI will: characterize and optimize the process of rapid pneumatic insertion, develop novel techniques for manipulating high electrode count arrays in situ, implement a chronic recording system for rats based on a new 16-pin high density connector, and investigate the manufacturing of novel multi-electrode architectures. These technologies will be evaluated in a series of acute experiments, conducted by the Center for Neural Interfaces at the University of Utah, designed to elucidate the interactions between large numbers of mitral cells during olfactory sensory processing. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（改编自申请人的摘要）：在所有人类感官 涉及化学检测（即味觉和嗅觉）的方式仍然存在， 最不理解的。尽管最近的一些报告令人兴奋， 他们使用各种成像方式来研究空间 组织的嗅球，目前还没有工具， 同时研究神经元的精细时空结构， 嗅球中的集合体。在第一阶段，仿生技术公司（BTI） 成功地证明了微电极阵列的应用， 大鼠嗅球感觉加工的研究根据这些 第二阶段建议解决部署中的几个关键问题， 神经科学界对这项技术的研究在一个独特的合作， 神经科学家，BTI将：表征和优化的过程，快速 气动插入，开发操作高位电极的新技术 在原位计数阵列，实现大鼠慢性记录系统的基础上， 新的16针高密度连接器，并探讨制造新的 多电极结构。这些技术将在一系列评估 急性实验，由神经接口中心在 犹他州大学，旨在阐明大的 在嗅觉感觉处理过程中的二尖瓣细胞的数量。 拟定商业应用： 不可用