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MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS

用于嗅觉研究的多电极阵列

基本信息

批准号：
6021785
负责人：
BRIAN W HATT
金额：
$ 10.36万
依托单位：
BIONIC TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-09-01 至 2000-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6021785
关键词：
biomedical equipment development brain electrical activity electronic recording system implant laboratory rat microelectrodes olfactions olfactory lobe

项目摘要

This proposal addresses the need, identified by the National Institute on Deafness and Other Communication Disorders, for the "Adaptation of multiple array electrodes for use in chemosensory electrophysiological studies". The goal is the development of a biologically-based olfactant recognition system. A 100-electrode array will be modified to provide tools and techniques that can be used by neuroscientists in the investigation of the olfactory system. These tools will also provide the basis for the development of implanted animals in the detection of explosives and drugs of abuse by the military and the law enforcement communities. Phase I will demonstrate the feasibility of using these arrays as the basis for tools and techniques for the electrophysiological study of the olfactory bulb. Acute implantation in rats will verify that olfactant-driven responses can be recorded, and the use of simultaneous recordings from large populations of neurons in olfactory bulb will be investigated for their potential application to discriminating olfactants. Phase II will further develop these tools to study whether simultaneous recordings from large numbers of spiking neurons in the olfactory bulb can be used to reliably discriminate between a large variety of olfactants. PROPOSED COMMERCIAL APPLICATIONS: The chronic and acute systems will be marketed to researchers worldwide for the investigation of olfactory processes using animal subjects such as rats and dogs. The system will also be adapted to implantation in animals for the detection of explosives and drugs of abuse by the military and the law enforcement communities

该提案解决了国家耳聋和其他沟通障碍研究所确定的“调整多个阵列电极用于化学感觉电生理研究”的需求。我们的目标是开发一个基于生物学的嗅觉识别系统。一个100个电极的阵列将被修改，以提供工具和技术，可用于神经科学家在嗅觉系统的调查。这些工具还将为军方和执法部门开发用于探测爆炸物和滥用药物的植入动物奠定基础。第一阶段将证明使用这些阵列作为工具和技术的基础上的嗅球的电生理研究的可行性。急性植入大鼠将验证，嗅觉驱动的反应可以记录，并使用同时记录从大量的神经元在嗅球将调查其潜在的应用程序，以区分嗅觉。第二阶段将进一步开发这些工具，以研究嗅球中大量尖峰神经元的同时记录是否可用于可靠地区分各种各样的嗅觉。拟议的商业应用：慢性和急性系统将销售给世界各地的研究人员，用于使用大鼠和狗等动物受试者研究嗅觉过程。该系统还将进行调整，以植入动物体内，用于检测军方和执法部门滥用的爆炸物和毒品