OMMAYA ARTIFICIAL ORGAN FOR ISLET TRANSPLANTATION

OMMAYA 胰岛移植人工器官

• 批准号: 2422439
• 负责人: AYUB K OMMAYA
• 金额: $ 42.38万
• 依托单位: CYBORGAN, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-08-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2422439
• 关键词: Macaca mulatta; artificial endocrine pancreas; biomaterial development /preparation; biomaterial evaluation; cerebrospinal fluid; insulin; noninsulin dependent diabetes mellitus; pancreatic islet transplantation; pancreatic islets; pharmacokinetics; secretion; tissue /cell culture; xenotransplantation

DESCRIPTION (Adapted from applicant's abstract): The investigator aims to complete the pre-clinical development and testing of an artificial pancreatic organ driven by cerebral spinal fluid by placing in CSF shunted in non-insulin dependent diabetic rhesus monkeys. To demonstrate the compatibility of xenogeneic islet cells to survive and to produce insulin in response to CSF glucose levels. The pharmacokinetics of substances placed into the CSF of monkeys via the Ommaya CSF reservoirs are comparable to those of human CSF. The investigators will evaluate long term host sensitization by xenogeneic islet cells using measurements of cellular and hormonal immune response for one year. The goal is to obtain FDA approval in order to offer this approach to IDDM patients with co-existing hydrocephalus in whom CFS shunts are already present. May also be available to brittle IDDM patients if diabetic hydrocephalic patients treatment are successful and currently low risk. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人摘要）：研究者旨在 完成人工胰腺的临床前开发和测试 脑脊液驱动器官置入脑脊液非胰岛素分流 依赖性糖尿病恒河猴。 为了证明 异种胰岛细胞存活并响应CSF产生胰岛素 葡萄糖水平 CSF中物质的药代动力学 猴通过Ommaya CSF储库的CSF的量与人CSF的量相当。 研究者将评估异种免疫的长期宿主致敏性。 胰岛细胞使用细胞和激素免疫反应的测量， 一年 我们的目标是获得FDA的批准，以提供这种方法 合并脑积水的IDDM患者，其中CFS分流已经 礼物如果糖尿病性脑积水患者 治疗是成功的，目前风险很低。 拟议商业应用：不可用