MOTOR COMPONENTS IN MOTOR SKILL LEARNING AND PERFORMANCE

这个项目的目标是了解神经表征是如何 简单的动作结合起来学习和表演复杂的运动技能。 学习表演许多复杂的、连续的动作，包括 乐器，从事一项运动，说话或写作 被视为已学习的运动片段或 “原语”以新奇的方式捆绑在一起。多声道录音 将使用一种新型的100电极阵列植入初级 (MI)和辅助运动区(SMA)，而 动物学习手部和手臂的连续动作。 理论工作表明，这种结合过程可能表现为 神经元集合之间的时间相互作用。时间交互作用 MI和SMA神经元之间的相关放电模式将是 当运动片段作为功能部件一起执行时进行检查 单位，并与当相同的分段被 独立地或孤立地产生的。一些运动障碍 例如帕金森氏症可以被描述为 生成流畅的运动序列。因此，这项研究可以 提供对此类疾病的病因和治疗的见解。

The goal of this project is to understand how neural representations of simple movements are combined to learn and perform complex, motor skills. Learning to perform many complex, sequential movements including play a musical instrument, engaging in a sport, speaking, or writing can be viewed as the process by which already learned movement segments or "primitives" are bound together in novel ways. Multi-channel recordings will be made using a novel 100 electrode array implanted in the primary (MI) and supplementary motor areas (SMA) of monkey cortex while the animals learns to perform sequential movements of the hand and arm. Theoretical work suggests that this binding process may manifest itself as temporal interactions among ensembles of neurons. Temporal interaction patterns such as correlated discharge among MI and SMA neurons will be examined when movement segments are performed together as a functional unit and compared with patterns occurring when the same segments are generated independently or in isolation. A number of movement disorders such as Parkinson's disease can be characterized as a breakdown in the generation of smooth movement sequences. Therefore, this research could provide insights into the etiology and treatment of such disorders.