EFFECTS OF PDT & GAMMA RADIATION ON HUMAN GLIOMA SPHEROIDS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究项目的总体目标是探讨光动力疗法（PDT）治疗恶性脑肿瘤（胶质瘤）的效用。 该项目是美国和挪威各机构密切和综合的多学科合作努力。参与方包括：Rikshospital神经外科部门、美国加利福尼亚州欧文市（UCI）贝克曼激光研究所和医疗诊所（BLI）的激光微束和医疗项目（LAMMP）机构、美国内华达州拉斯维加斯市（UNLV）内华达大学健康物理系。以及挪威奥斯陆镭医院的外科肿瘤科和病理科。 以往研究的目的是确定光动力疗法联合电离辐射或同时热疗治疗多形性胶质母细胞瘤的效用。 本文详细研究了光剂量、γ射线剂量、温度和光敏剂种类对人脑胶质瘤球状体的影响。 该项目还研究了过去几年中ALA酯和重复PDT治疗的PDT效应，并发表了几篇研究论文。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall objective of this research project is to investigate the utility of photodynamic therapy (PDT) for the treatment of malignant brain tumors (gliomas). The project is a close and integrated multi disciplinary collaborative effort of various institutions in he United States and Norway. The participating parties are: The Department of neurosurgery, Rikshospital, the Laser microbeam and medical program (LAMMP) facility at the Beckman Laser Institute and Medical Clinic (BLI), University of California, Irvine (UCI), California USA the Department of health physics at the University of Nevada, Las Vegas (UNLV), Nevada USA. and the Departments of surgical oncology, and pathology the Norwegian Radium Hospital.Oslo Norway. The aim of previous investigations was to determine the utility of photodynamic therapy in combination with ionizing radiation or concurrent hyperthermia in the treatment of glioblastoma multiforme. The effects of light dose, gamma radiation dose, temperature and photosensitizer type on human glioma spheroids have been investigated in detail. The project also investigated the PDT effect of ALA-ester and repetitive PDT treatments during the past few years with several publications resulted from the study.