GCRF: The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network: a sub-Saharan network for placental disorders

GCRF：精准（无处不在的转化科学孕期护理）网络：撒哈拉以南胎盘疾病网络

• 批准号: MR/P027938/1
• 负责人: Peter Von Dadelszen
• 金额: $ 1009.41万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FP027938%2F1
• 关键词: GCRF; PRECISE; PREgnancy; Care; Integrating

The PRECISE Network is a new and broadly-based group of research scientists and health advocates mainly based in the UK and Africa, but also including the World Health Organization. We will establish this network through a shared project that will investigate three important complications of pregnancy, namely high blood pressure (hypertension), babies who are smaller than they should be before birth (fetal growth restriction) and babies who die before birth (stillbirth). We think that about 46,000 women and two-and-a-half million babies (both before and after birth) die due to these problems every year, and half of them die in Africa. In addition, about 50 million women and babies will have their short and long term health altered because of these complications. These numbers represent one of the great global inequalities of our time.In developed countries like the UK, we know that these three pregnancy complications are caused by problems with the afterbirth (placenta), and we know quite a lot about how they develop and complicate pregnancies. In contrast, in sub-Saharan Africa, we know very little about how and why these placental conditions occur. This is especially complex as women in Africa often have many other challenges: limited diets that change with the seasons, chronic infections such as HIV or malaria, acute infections like Ebola, limited power to make decisions for themselves, life in communities that are prone to either flooding or drought and are remote from health facilities. Therefore, the way that pregnancy complications arise are probably very different for these women in sub-Saharan Africa, compared with women living in the UK. Yet, these women and their babies bear most of the burden of death and illness related to pregnancy complications. We need to address this area of neglected global health research. In PRECISE, we will train and mentor junior investigators in how to do pregnancy research, and we will establish new databases related to pregnant and some non-pregnant women, the context of their lives, their pregnancy complications and what happens at the end of their pregnancies. We will save samples of blood, urine and placental tissue, and test them to increase our knowledge about how women's bodies cope with both normal and complicated pregnancies. All the samples and the data will remain in Africa for use primarily by Africans in collaboration with UK-based and other scientists.To have a sample of pregnancies that are typical of women in sub-Saharan Africa, we will invite about 12,000 women in The Gambia and Senegal (West Africa), Kenya (East Africa) and Mozambique (Southern Africa) to share their stories, the data related to their pregnancy and babies, and their blood, urine and placental samples with their regional team and the wider global research community, especially the PRECISE scientists. This large number of women will allow us to gain new and important insights into how and why women in sub-Saharan Africa develop these pregnancy complications, and how and why may of them and their babies die from these complications. Through these activities, we hope to improve the health and well-being of women and their families in Africa, to build resilience to environmental events such as flooding or infectious disease outbreaks, to advise about where infrastructure such as roads will improve pregnancy outcomes, and to reduce the inequality of maternal and child deaths that is visited on families in sub-Saharan Africa.

PRECISE网络是一个新的、基础广泛的研究科学家和健康倡导者团体，主要设在英国和非洲，但也包括世界卫生组织。我们将通过一个共同项目建立这一网络，该项目将调查三种重要的妊娠并发症，即高血压（高血压）、婴儿小于出生前应有的尺寸（胎儿生长受限）和婴儿在出生前死亡（死产）。我们认为，每年约有46 000名妇女和250万婴儿（包括出生前和出生后）死于这些问题，其中一半死于非洲。此外，约5000万妇女和婴儿的短期和长期健康将因这些并发症而改变。这些数字代表了我们这个时代最大的全球不平等之一。在英国这样的发达国家，我们知道这三种妊娠并发症是由胎盘问题引起的，我们对它们如何发展和使妊娠复杂化有很多了解。相比之下，在撒哈拉以南非洲，我们对这些胎盘条件如何以及为什么发生知之甚少。这一点尤其复杂，因为非洲妇女往往面临许多其他挑战：饮食有限，随季节变化，艾滋病毒或疟疾等慢性感染，埃博拉等急性感染，为自己做决定的权力有限，生活在容易发生洪水或干旱的社区，远离卫生设施。因此，与生活在英国的妇女相比，撒哈拉以南非洲妇女的妊娠并发症发生方式可能非常不同。然而，这些妇女和她们的婴儿承担着与妊娠并发症有关的死亡和疾病的大部分负担。我们需要解决这一被忽视的全球卫生研究领域。在PRECISE，我们将培训和指导初级研究人员如何进行妊娠研究，我们将建立与妊娠和一些非妊娠妇女有关的新数据库，他们的生活背景，妊娠并发症以及妊娠结束时发生的情况。我们将保存血液、尿液和胎盘组织的样本，并对其进行测试，以增加我们对女性身体如何科普正常和复杂妊娠的知识。所有的样本和数据将留在非洲，主要由非洲人与英国和其他科学家合作使用。为了获得撒哈拉以南非洲妇女的典型怀孕样本，我们将邀请冈比亚和塞内加尔的约12，000名妇女（西非），肯尼亚（东非）和莫桑比克（南部非洲）分享她们的故事，与她们怀孕和婴儿有关的数据，以及她们的血液，与其区域团队和更广泛的全球研究界，特别是PRECISE的科学家一起，对尿液和胎盘样本进行检测。这一大批妇女将使我们能够获得新的重要见解，了解撒哈拉以南非洲妇女如何以及为什么会患上这些妊娠并发症，以及她们和她们的婴儿如何以及为什么会死于这些并发症。通过这些活动，我们希望改善非洲妇女及其家庭的健康和福祉，建立对洪水或传染病爆发等环境事件的复原力，就道路等基础设施如何改善妊娠结果提供咨询，并减少撒哈拉以南非洲家庭面临的孕产妇和儿童死亡不平等。

项目成果

Risk factors for pre-eclampsia in clinical practice guidelines: Comparison with the evidence

• DOI: 10.1111/1471-0528.17320
• 发表时间: 2022-11-22
• 期刊: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
• 影响因子: 5.8
• 作者: Elawad, Terteel;Scott, Georgia;Magee, Laura A.
• 通讯作者: Magee, Laura A.

Introduction to artificial intelligence in ultrasound imaging in obstetrics and gynecology.

• DOI: 10.1002/uog.22122
• 发表时间: 2020-10
• 期刊: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
• 作者: Drukker L;Noble JA;Papageorghiou AT
• 通讯作者: Papageorghiou AT

Investigating placental disorders of pregnancy in sub-Saharan Africa: addressing the gap in a neglected area of research.

调查撒哈拉以南非洲地区妊娠胎盘疾病：弥补被忽视的研究领域的空白。

• DOI: 10.1186/s12978-020-0871-x
• 发表时间: 2020
• 期刊: Reproductive health
• 影响因子: 3.4
• 作者: Donnay F

A Dual Adversarial Calibration Framework for Automatic Fetal Brain Biometry

• DOI: 10.1109/iccvw54120.2021.00363
• 发表时间: 2021-08
• 期刊: 2021 IEEE/CVF International Conference on Computer Vision Workshops (ICCVW)
• 作者: Yuan Gao;Lok Hin Lee;Richard Droste;R. Craik;Sridevi Beriwal;A. Papageorghiou;A. Noble

Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review.

• DOI: 10.1136/bmjgh-2020-003716
• 发表时间: 2020-11
• 期刊: BMJ global health
• 影响因子: 8.1
• 作者: Bone JN;Pickerill K;Woo Kinshella ML;Vidler M;Craik R;Poston L;Stones W;Sevene E;Temmerman M;Koech Etyang A;Roca A;Russell D;Tribe RM;von Dadelszen P;Magee LA;PRECISE Network
• 通讯作者: PRECISE Network