DIETARY PATTERNS, ANTIOXIDANTS AND LIPID PEROXIDATION

饮食模式、抗氧化剂和脂质过氧化

• 批准号: 6030426
• 负责人: Edgar Raymond Miller
• 金额: $ 11.97万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-05 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6030426
• 关键词: age difference; antioxidants; atherosclerosis; autoantibody; biomarker; carotenoids; clinical research; diet; dietary constituent; dietary lipid; disease /disorder proneness /risk; gender difference; human subject; lipid peroxides; low density lipoprotein; nutrition related tag; pathologic process; peroxidation; retinoids; tobacco abuse; tocopherols; urinalysis

DESCRIPTION (Adapted from applicant's abstract) Dr. Edgar R. (Pete) Miller, III is a promising junior faculty member who has made a substantial commitment to a career in clinical research. Evidence of this commitment is his pursuit of advanced clinical and research training, including completion of a clinical investigator residency program in Internal Medicine, a research fellowship in General Internal Medicine and advanced training in cardiovascular disease prevention and epidemiology. This training provides a solid foundation for him to address clinical research problems in a methodologically rigorous fashion. His proposed study builds upon his previous research and addresses questions of fundamental importance related to lipid peroxidation, atherosclerosis and nutrition-based interventions that modify these processes. Oxidative modification of lipids by free radicals is thought to be an important, if not obligatory process in the formation of atherosclerosis. Measures of free radical-mediated damage to lipids including antibodies to oxidized-LDL cholesterol and products of in vivo lipid peroxidation should be useful markers of pre-morbid disease and provide potential therapeutic end-points for disease activity. The applicant for this Mentored Clinician Scientist Development Award (MCSDA) will conduct a trial which will improve the understanding of the role of these important intermediaries in the causal pathway of atherosclerosis, specifically addressing the question as to whether certain dietary consumption patterns will effect this process. The environment and resources available to the MCSDA candidate are impressive. Dr. Lawrence J. Appel, an accomplished investigator in cardiovascular disease prevention research, is the candidate's mentor and will serve as his sponsor. In this role, Dr. Appel will ensure that the candidate benefits from the tremendous resources of The Johns Hopkins Medical Institutions, particularly those of the Welch Center for Prevention, Epidemiology and Clinical Research. Receipt of this MCSDA will compliment those resources by providing the candidate with the protected time necessary for him to reach his full potential as a clinical investigator.

描述 （改编自申请人摘要）埃德加博士R。（皮特）米勒，三是一个 一个有前途的年轻教师谁作出了实质性的承诺， 从事临床研究。 这一承诺的证据是他对 高级临床和研究培训，包括完成临床 内科学研究员住院医师项目，一项研究奖学金 普通内科和心血管疾病高级培训 预防和流行病学。 这一培训为以下方面奠定了坚实的基础： 他以严格的方法论解决临床研究问题， 时尚. 他提出的研究建立在他以前的研究和地址 与脂质过氧化有关的基本重要问题， 动脉粥样硬化和基于营养的干预，修改这些 流程. 自由基对脂质的氧化改性被认为是一种 在动脉粥样硬化的形成过程中，如果不是强制性的，也是重要的。 测量自由基介导的脂质损伤，包括抗 氧化LDL胆固醇和体内脂质过氧化产物应 是病前疾病的有用标志物， 疾病活动的终点。 该指导临床医生的申请人 科学家发展奖（MCSDA）将进行一项试验， 了解这些重要中介机构在 动脉粥样硬化的因果途径，特别是解决这个问题， 某些饮食消费模式是否会影响这一过程。 MCSDA候选人可用的环境和资源是 人印象深刻. Lawrence J.阿佩尔博士是一位在 心血管疾病预防研究，是候选人的导师， 将作为他的担保人 在这个角色中，阿佩尔博士将确保 候选人受益于约翰霍普金斯的巨大资源 医疗机构，特别是韦尔奇预防中心， 流行病学和临床研究。 收到这份MCSDA将赞扬 通过为候选人提供必要的受保护的时间， 让他充分发挥临床调查员的潜力