DIETARY PATTERNS, ANTIOXIDANTS AND LIPID PEROXIDATION

描述 (改编自申请人的摘要)埃德加·R(皮特)·米勒博士，III是一名 有前途的初级教职员工，他们对 从事临床研究。这一承诺的证据是他对 高级临床和研究培训，包括完成临床 内科研究员住院医师计划，研究奖学金 普通内科和心血管疾病高级培训 预防和流行病学。该培训为以下项目奠定了坚实的基础 他将以严谨的方法解决临床研究问题 时尚。他提出的研究建立在他之前的研究基础上，并提出了 与脂质过氧化有关的基本重要问题， 动脉粥样硬化和基于营养的干预措施改变这些 流程。 自由基氧化修饰脂质被认为是一种 动脉粥样硬化的形成过程即使不是强制性的，也是重要的。 自由基介导的脂类损伤的测量方法，包括抗体 氧化低密度脂蛋白胆固醇和体内脂质过氧化产物应 是疾病前的有用标志，并提供潜在的治疗方法 疾病活动的终点。这位临床指导医生的申请人 科学家发展奖(MCSDA)将进行一项试验，将改善 对这些重要中介机构在经济增长中作用的理解 动脉粥样硬化的致病途径，具体解决如下问题 某些饮食消费模式是否会影响这一过程。 可供MCSDA候选人使用的环境和资源包括 令人印象深刻。劳伦斯·J·阿佩尔博士，一位成就卓著的调查员 心血管疾病预防研究，是候选人的导师和 将作为他的赞助商。在这一角色中，阿佩尔博士将确保 候选人受益于约翰·霍普金斯大学的巨大资源 医疗机构，特别是韦尔奇预防中心的医疗机构， 流行病学和临床研究。收到此MCSDA将获得赞誉 通过为候选人提供必要的受保护时间来提供这些资源 让他充分发挥他作为临床研究员的潜力。

DESCRIPTION (Adapted from applicant's abstract) Dr. Edgar R. (Pete) Miller, III is a promising junior faculty member who has made a substantial commitment to a career in clinical research. Evidence of this commitment is his pursuit of advanced clinical and research training, including completion of a clinical investigator residency program in Internal Medicine, a research fellowship in General Internal Medicine and advanced training in cardiovascular disease prevention and epidemiology. This training provides a solid foundation for him to address clinical research problems in a methodologically rigorous fashion. His proposed study builds upon his previous research and addresses questions of fundamental importance related to lipid peroxidation, atherosclerosis and nutrition-based interventions that modify these processes. Oxidative modification of lipids by free radicals is thought to be an important, if not obligatory process in the formation of atherosclerosis. Measures of free radical-mediated damage to lipids including antibodies to oxidized-LDL cholesterol and products of in vivo lipid peroxidation should be useful markers of pre-morbid disease and provide potential therapeutic end-points for disease activity. The applicant for this Mentored Clinician Scientist Development Award (MCSDA) will conduct a trial which will improve the understanding of the role of these important intermediaries in the causal pathway of atherosclerosis, specifically addressing the question as to whether certain dietary consumption patterns will effect this process. The environment and resources available to the MCSDA candidate are impressive. Dr. Lawrence J. Appel, an accomplished investigator in cardiovascular disease prevention research, is the candidate's mentor and will serve as his sponsor. In this role, Dr. Appel will ensure that the candidate benefits from the tremendous resources of The Johns Hopkins Medical Institutions, particularly those of the Welch Center for Prevention, Epidemiology and Clinical Research. Receipt of this MCSDA will compliment those resources by providing the candidate with the protected time necessary for him to reach his full potential as a clinical investigator.