COLLAGEN COIL FOR TREATMENT OF CEREBRAL ANEURYSMS

用于治疗脑动脉瘤的胶原弹簧圈

• 批准号: 6210775
• 负责人: SHU-TUNG T LI
• 金额: $ 12.01万
• 依托单位: COLLAGEN MATRIX, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6210775
• 关键词: angiography; cerebral aneurysm; cerebrovascular occlusions; collagen; drug delivery systems; drug design /synthesis /production; histology; laboratory rabbit; tissue /cell culture

DESCRIPTION (Adapted from the Applicant's Abstract):The aim of the proposed research is to design, develop and test the in-vivo biologically active collagen based coil for embolizing cerebral aneurysm by improving the overall design and quality of the prototype achieved in the Phase I. Specifically, the investigators propose to design and fabricate an improved collagen coil prototype such that it will be suitable for in-vivo investigations. They also will develop low profile delivery system as a micro catheter of 3 French or smaller with a visibility provided under fluoroscopy. Finally, they would conduct an in-vivo test in rabbits and perform angiographic and histological analyses to test the effectiveness of the collagen coil in inducing occlusion thrombus organization, fibrosis and neo intima formation in the aneurysm. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：拟议的目的 研究是设计、开发和测试体内生物活性 基于胶原蛋白的线圈通过改善整体栓塞脑动脉瘤 第一阶段实现的原型的设计和质量。具体来说， 研究人员建议设计和制造改进的胶原蛋白线圈 原型，使其适合体内研究。他们还 将开发低轮廓输送系统作为 3 法国或 较小，在透视下提供可见度。 最后，他们将在兔子身上进行体内测试并进行血管造影 和组织学分析来测试胶原蛋白线圈的有效性 诱导闭塞血栓组织、纤维化和新内膜形成 动脉瘤。 拟议的商业应用：不可用

项目成果

A collagen-based coil for embolization of saccular aneurysms in a New Zealand White rabbit model.

一种基于胶原蛋白的弹簧圈，用于新西兰白兔模型中囊状动脉瘤的栓塞。

• 发表时间: 2003
• 期刊: AJNR. American journal of neuroradiology
• 作者: Kallmes,DavidF;Fujiwara,NaomiH;Yuen,Debbie;Dai,Daying;Li,Shu-Tung
• 通讯作者: Li,Shu-Tung