Type 1 Collagen-Based Nerve Guide for PNS Regeneration

用于 PNS 再生的 1 型胶原神经导管

• 批准号: 6603921
• 负责人: SHU-TUNG T LI
• 金额: $ 67.19万
• 依托单位: COLLAGEN MATRIX, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-17 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6603921
• 关键词: Primates; bioengineering /biomedical engineering; collagen; cooperative study; extracellular matrix; laboratory rat; nervous system regeneration; peripheral nervous system

This proposal is a collaboration of multidisciplinary fields of peripheral nerve repair and regeneration, involving Collagen Matrix, Inc., leading the BRP, specializing in extracellular matrix design and engineering; Eastern Virginia Medical School, specializing in neuroscience and neurosurgery; Duke University specializing in neuroscience, entubulation repair of peripheral nerve, clinical neurology and urology; and University of . South Florida, specializing in clinical urology. The overall goal of this research partnership proposal is to design, engineer and evaluate in vivo a type I collagen-based bioactive nerve guide for peripheral nerve regeneration applications. The research team, through joint effort of the partnership, applies the current state-of-the- art knowledge of matrix technology, protein chemistry, neuroscience, neurosurgery and clinical urology to systematically evaluate the key design parameters. This systematic approach will lead to the development of a nerve guide that has the high probability of clinical success in nerve regeneration. The specific objectives of the proposal involve the isolation of the key design parameters and testing them in a rat sciatic nerve model. The final prototype, engineered from optimal design parameters, will be evaluated in two primate nerve models (median and cavernosal) as a potential entubulation repair method for clinical application. In the first year we will isolate the design parameters and engineer the prototypes. In subsequent years, we will characterize the prototypes, test in vivo performance of the prototypes in a rat model, finalize the overall design, and finally, evaluate the final prototype in primate models. The overall program is designed for five years.

该提案是周围神经修复和再生多学科领域的合作，涉及领导 BRP 的 Collagen Matrix, Inc.，专门从事细胞外基质设计和工程；东弗吉尼亚医学院，专攻神经科学和神经外科；杜克大学专长神经科学、周围神经插管修复、临床神经病学和泌尿外科；和大学。 南佛罗里达州，专攻临床泌尿外科。该研究合作提案的总体目标是设计、工程和评估体内基于 I 型胶原的生物活性神经导管，用于周围神经再生应用。通过合作伙伴的共同努力，研究团队应用当前最先进的基质技术、蛋白质化学、神经科学、神经外科和临床泌尿学知识来系统地评估关键设计参数。这种系统方法将导致神经导管的开发，该神经导管在神经再生方面很有可能获得临床成功。该提案的具体目标包括分离关键设计参数并在大鼠坐骨神经模型中对其进行测试。根据最佳设计参数设计的最终原型将在两种灵长类神经模型（正中神经和海绵体神经）中进行评估，作为临床应用的潜在插管修复方法。在第一年，我们将隔离设计参数并设计原型。在接下来的几年中，我们将对原型进行表征，在大鼠模型中测试原型的体内性能，最终确定总体设计，最后在灵长类动物模型中评估最终原型。总体方案设计时间为五年。