Collagen -based Coil for Treatment of Cerebral Aneurysms

描述(由申请人提供)： 这项研究的总体目标是设计、开发和体内测试一种具有生物活性的胶原基弹簧圈，用于脑动脉瘤的栓塞。我们的研究假设是I型胶原基材料将促进和促进动脉瘤腔内纤维组织的形成，因此，将稳定动脉瘤以有效地闭塞动脉瘤。这一假说建立在大量研究的基础上，即胶原表面促进了细胞的黏附、增殖和细胞外基质的合成，所有这些都有助于纤维化的形成和纤维组织的沉积，导致稳定的动脉瘤闭塞。在第一阶段，我们开发了一种基于胶原的弹簧圈原型，并在兔球囊动脉瘤模型上进行了体外和体内测试。体内研究结果表明，用提纯的I型胶原构建的弹簧圈栓塞囊状动脉瘤是可行的。然而，在胶原基线圈可以用于临床之前，有几个方面需要改进。线圈必须是可交付的、可拆卸的、活体可见的和可回收的。这些改进将是第二阶段提案的主题。

DESCRIPTION (provided by applicant): The overall goal of this research is the design, development and in vivo testing of a biologically active, collagen-based coil for the embolization of cerebral aneurysms. Our research hypothesis for this investigation is that type I collagen-based material will promote and facilitate fibrous tissue formation within the aneurysm cavity and therefore, will stabilize the aneurysm for effective aneurysm occlusion. The hypothesis is based on numerous previous studies that collagen surface enhances cell adhesion, proliferation and extracellular cellular matrix synthesis, all of which contribute to fibrogenesis and fibrous tissue deposition, resulting in stable aneurysm occlusion. In phase I, we have developed a collagen-based coil prototype and tested the prototypes in vitro and in vivo in a rabbit saccular aneurysm model. Results of the in vivo studies demonstrated the feasibility of embolizing saccular aneurysms using coils constructed from purified type I collagen. However, several areas require improvement before the collagen-based coil can be used clinically. The coil must be deliverable, detachable, visible in vivo and retrievable. These improvements will be the subject of this phase II proposal.