Collagen -based Coil for Treatment of Cerebral Aneurysms

用于治疗脑动脉瘤的胶原弹簧圈

• 批准号: 6690521
• 负责人: SHU-TUNG T LI
• 金额: $ 40.21万
• 依托单位: COLLAGEN MATRIX, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690521
• 关键词: angiography; cardiovascular disorder therapy; cerebral aneurysm; cerebrovascular occlusions; collagen; disease /disorder model; histology; implant; laboratory rabbit; medical implant science; nonhuman therapy evaluation; technology /technique development

DESCRIPTION (provided by applicant): The overall goal of this research is the design, development and in vivo testing of a biologically active, collagen-based coil for the embolization of cerebral aneurysms. Our research hypothesis for this investigation is that type I collagen-based material will promote and facilitate fibrous tissue formation within the aneurysm cavity and therefore, will stabilize the aneurysm for effective aneurysm occlusion. The hypothesis is based on numerous previous studies that collagen surface enhances cell adhesion, proliferation and extracellular cellular matrix synthesis, all of which contribute to fibrogenesis and fibrous tissue deposition, resulting in stable aneurysm occlusion. In phase I, we have developed a collagen-based coil prototype and tested the prototypes in vitro and in vivo in a rabbit saccular aneurysm model. Results of the in vivo studies demonstrated the feasibility of embolizing saccular aneurysms using coils constructed from purified type I collagen. However, several areas require improvement before the collagen-based coil can be used clinically. The coil must be deliverable, detachable, visible in vivo and retrievable. These improvements will be the subject of this phase II proposal.

描述（由申请人提供）： 本研究的总体目标是设计、开发和体内测试用于脑动脉瘤栓塞的生物活性胶原基弹簧圈。本研究的研究假设是，I型胶原基材料将促进和促进动脉瘤腔内的纤维组织形成，因此，将稳定动脉瘤以实现有效的动脉瘤闭塞。该假设基于大量先前的研究，即胶原蛋白表面增强细胞粘附、增殖和细胞外基质合成，所有这些都有助于纤维形成和纤维组织沉积，从而导致稳定的动脉瘤闭塞。在第一阶段，我们已经开发了一种基于胶原的弹簧圈原型，并在兔囊状动脉瘤模型中进行了体外和体内测试。体内研究的结果证明了使用纯化I型胶原构建的弹簧圈栓塞囊状动脉瘤的可行性。然而，在基于胶原的线圈可以用于临床之前，有几个领域需要改进。弹簧圈必须可输送、可分离、在体内可见且可回收。这些改进将成为第二阶段提案的主题。