TYPE I COLLAGEN MATRIX REFERENCE MATERIALS FOR TISSUES

I 型胶原蛋白基质组织参考材料

• 批准号: 2747680
• 负责人: SHU-TUNG T LI
• 金额: $ 9.79万
• 依托单位: COLLAGEN MATRIX, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2747680
• 关键词: biomaterial development /preparation; collagen; extracellular matrix; method development; protein purification; tissue /cell culture; tissue engineering; tissue support frame; wound healing

DESCRIPTION (adapted from applicant's abstract): Tissue engineering is an interdisciplinary science of biology, physical sciences, engineering and medicine. The three key components of tissue engineering products (or engineered tissue products) are the extracellular matrix, the cells and the regulatory signals (tissue specific induction factor and/or growth factors). I order to effectively evaluate these components in a systematic way, the investigators propose to provide the tissue engineering community with a series of type I collagen matrix reference materials for engineering research. In phase I, a series of type I collagen matrix reference materials will be designed and developed. They include porous, tubular, membrane, filament, and fibrillar matrices of defined characteristics and properties that are suitable for a variety of tissue and organ repair and regeneration tissue engineering product research and development. In phase II, these matrices will be fabricated and tested in vitro with various types of cells that are pertinent for particular tissue regeneration applications. The state-of-the-art of repair of damaged tissue or organ is by tissue engineering products, which can be used either to replace or correct poorly functional components in humans or to introduce better functional components into these living systems. The introduction of tissue matrix reference materials will greatly facilitate the tissue engineering product development. The investigators anticipate a wide range of applications of the tissue matrix reference materials in tissue engineering product research and development. Thus, the commercial value of the reference materials is clearly identified. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人摘要）：组织工程是一种 生物学、物理科学、工程学和 药 组织工程产品的三个关键组成部分（或 工程组织产品）是细胞外基质，细胞和 调节信号（组织特异性诱导因子和/或生长 因素）。为了有效地评估这些组件， 研究人员建议为组织工程界提供 使用一系列I型胶原基质参比材料， 工程研究 在I期，一系列I型胶原基质 将设计和编制参考材料。 它们包括多孔的， 管状、膜状、丝状和纤维状基质， 适用于各种组织的特性和性质 以及器官修复与再生组织工程产品研究， 发展 在第二阶段，这些矩阵将被制造和测试， 用与特定组织相关的各种类型的细胞进行体外培养 再生应用。损伤修复的最新技术 组织或器官是由组织工程产品，它可以使用 或者替换或纠正人体中功能不良的成分， 为这些生命系统引入更好的功能组件。 的 组织基质参考材料的引入将极大地促进 组织工程产品开发。 调查人员预计， 组织基质标准物质的广泛应用， 组织工程产品研发。 因此，商业 参考材料的价值得到明确识别。 拟议商业应用：不可用