Type 1 Collagen-Based Nerve Guide for PNS Regeneration

用于 PNS 再生的 1 型胶原神经导管

• 批准号: 6776450
• 负责人: SHU-TUNG T LI
• 金额: $ 57.68万
• 依托单位: COLLAGEN MATRIX, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-17 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6776450
• 关键词: Primates; bioengineering /biomedical engineering; collagen; cooperative study; extracellular matrix; laboratory rat; nervous system regeneration; peripheral nervous system

This proposal is a collaboration of multidisciplinary fields of peripheral nerve repair and regeneration, involving Collagen Matrix, Inc., leading the BRP, specializing in extracellular matrix design and engineering; Eastern Virginia Medical School, specializing in neuroscience and neurosurgery; Duke University specializing in neuroscience, entubulation repair of peripheral nerve, clinical neurology and urology; and University of . South Florida, specializing in clinical urology. The overall goal of this research partnership proposal is to design, engineer and evaluate in vivo a type I collagen-based bioactive nerve guide for peripheral nerve regeneration applications. The research team, through joint effort of the partnership, applies the current state-of-the- art knowledge of matrix technology, protein chemistry, neuroscience, neurosurgery and clinical urology to systematically evaluate the key design parameters. This systematic approach will lead to the development of a nerve guide that has the high probability of clinical success in nerve regeneration. The specific objectives of the proposal involve the isolation of the key design parameters and testing them in a rat sciatic nerve model. The final prototype, engineered from optimal design parameters, will be evaluated in two primate nerve models (median and cavernosal) as a potential entubulation repair method for clinical application. In the first year we will isolate the design parameters and engineer the prototypes. In subsequent years, we will characterize the prototypes, test in vivo performance of the prototypes in a rat model, finalize the overall design, and finally, evaluate the final prototype in primate models. The overall program is designed for five years.

这项建议是周围神经修复和再生的多学科领域的合作，涉及领导BRP的胶原蛋白矩阵公司，专门从事细胞外基质设计和工程；东弗吉尼亚医学院，专门从事神经科学和神经外科；杜克大学，专门从事神经科学，周围神经插管修复，临床神经学和泌尿学；以及加州大学。南佛罗里达，专攻临床泌尿科。这项研究合作计划的总体目标是设计、设计和在体内评估一种基于I型胶原蛋白的生物活性神经指南，用于周围神经再生应用。研究团队通过合作伙伴的共同努力，应用当前最先进的基质技术、蛋白质化学、神经科学、神经外科和临床泌尿外科知识来系统地评估关键设计参数。这种系统的方法将导致神经指南的开发，这种指南在神经再生方面具有很高的临床成功几率。该提案的具体目标包括分离关键设计参数并在大鼠坐骨神经模型中进行测试。最终的原型，根据最佳的设计参数设计，将在两个灵长类神经模型(正中和海绵体)中进行评估，作为一种潜在的临床应用的咬合修复方法。在第一年，我们将分离设计参数并设计原型。在接下来的几年里，我们将对原型进行表征，在大鼠模型上测试原型的体内性能，最终完成总体设计，最后在灵长类动物模型中评估最终的原型。整个项目的设计时间为五年。