DISPOSABLE, MAGNETICALLY SUSPENDED BLOOD PUMP

一次性磁悬浮血泵

• 批准号: 6072178
• 负责人: HSIANG M CHEN
• 金额: $ 14.47万
• 依托单位: FOSTER-MILLER TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6072178
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; circulatory assist; consumable /disposable biomedical equipment; extracorporeal circulation; heart /lung bypass; magnetic field

DESCRIPTION. (Adapted From Applicant's Abstract): Disposable centrifugal pumps are now a well-accepted blood-pumping modality in cardiopulmonary bypass circuits, postcardiotomy assist cases, and ECMO applications. The long-term objective of the proposed project is to extend the current technology by developing an innovative magnetically suspended pump, which eliminates the bearings, shaft and seals commonly found in existing products, along with their associated costs and propensity for mechanical failures and clot initiation. The design allows for a gap in the radial magnetic bearing, which provides a return path for blood flow to wash the rear of the rotor. The pump will be as functional as existing products, and will be superior in durability and blood compatibility as the duration of pumping increases. In Phase I, the specific aims are to (1) design a disposable centrifugal pump capable of a pressure rise of 350 mmHg with a flow of four liters/minute; (2) design a motor and magnetic bearing system suitable to rotate and suspend the rotor; (3) build a prototype system; and (4) test that system for hydraulic performance and hemolysis. In Phase II, the product version of the pump will be designed, built, and extensively tested in animal CPB and ECMO studies. PROPOSED COMMERCIAL APPLICATION: Potential commercial applications inculde cardiopulmonary bypass (CPB) circuits, postcardiotomy- assist cases, and extracorporeal membrane oxygenation (ECMO). The magnetically levitated disposable blood pump is expected to provide economical performance for short-term, single- use indications, and its reusable motor-bearing assembly is durable, for longer duration, temporary, and bridge pump applications. Additionally, it can be located on the OR table, with special catheter set, for minimally invasive surgical procedures.

描述。 （改编自申请人的摘要）：一次性离心泵 现在是体外循环中广泛接受的抽血方式 电路、心切开术后辅助病例和 ECMO 应用。长期来看 拟议项目的目标是通过以下方式扩展当前技术 开发一种创新的磁悬浮泵，消除了 现有产品中常见的轴承、轴和密封件及其 相关成本以及机械故障和血栓形成的倾向。 该设计允许径向磁力轴承中存在间隙，从而提供 用于清洗转子后部的血流回流路径。泵将作为 功能与现有产品一样，并且在耐用性和血液方面将更加出色 兼容性随着泵送时间的增加而增加。在第一阶段，具体 目标是 (1) 设计一种能够升压的一次性离心泵 流量为 4 升/分钟，压力为 350 mmHg； (2)设计电机和磁力 适合旋转和悬挂转子的轴承系统； (3) 构建原型 系统; (4)测试该系统的水力性能和溶血。在 第二阶段，将设计、建造和生产泵的产品版本 在动物 CPB 和 ECMO 研究中进行了广泛测试。 拟议的商业应用： 潜在的商业应用包括心肺旁路 (CPB) 回路、心脏切开术后- 协助病例和体外膜肺氧合（ECMO）。 磁悬浮 一次性血泵有望为短期、单次使用提供经济的性能 使用指示，其可重复使用的电机轴承组件耐用、持续时间较长、临时、 和桥泵应用。 此外，它可以放置在手术台上，配有特殊的导管 设置，用于微创外科手术。