DISPOSABLE, MAGNETICALLY SUSPENDED BLOOD PUMP

说明.（改编自申请人摘要）：一次性离心泵 现在是心肺分流术中广泛接受的血液泵送方式 回路、心切开术后辅助病例和ECMO应用。长期 拟议项目的目标是通过以下方式扩展现有技术： 开发一种创新的磁悬浮泵， 现有产品中常见的轴承、轴和密封件，沿着 相关的成本和机械故障和凝块形成的倾向。 该设计允许在径向磁轴承中存在间隙，这提供了一种可调节性。 血液流动的返回路径，以清洗转子的后部。该泵将作为 功能与现有产品相同，并且在耐用性和血液方面具有上级优势 随着泵送持续时间的增加，在第一阶段，具体 目的是（1）设计一种能够增压的一次性离心泵， （2）设计了一个电机和磁力驱动器， 适合于旋转和悬挂转子的轴承系统;（3）建立原型 系统;和（4）测试系统水力性能和溶血。在 第二阶段，泵的产品版本将被设计，建造， 在动物CPB和ECMO研究中进行了广泛测试。 拟定商业应用： 潜在的商业应用包括心肺转流（CPB）回路、心切开术后- 辅助病例和体外膜肺氧合（ECMO）。 磁悬浮 一次性血泵有望为短期、单次、 使用适应症，并且其可重复使用的电机轴承组件是耐用的，持续时间更长，暂时的， 和桥式泵应用。 此外，它可以位于手术台上，带有特殊导管 套件，用于微创外科手术。

DESCRIPTION. (Adapted From Applicant's Abstract): Disposable centrifugal pumps are now a well-accepted blood-pumping modality in cardiopulmonary bypass circuits, postcardiotomy assist cases, and ECMO applications. The long-term objective of the proposed project is to extend the current technology by developing an innovative magnetically suspended pump, which eliminates the bearings, shaft and seals commonly found in existing products, along with their associated costs and propensity for mechanical failures and clot initiation. The design allows for a gap in the radial magnetic bearing, which provides a return path for blood flow to wash the rear of the rotor. The pump will be as functional as existing products, and will be superior in durability and blood compatibility as the duration of pumping increases. In Phase I, the specific aims are to (1) design a disposable centrifugal pump capable of a pressure rise of 350 mmHg with a flow of four liters/minute; (2) design a motor and magnetic bearing system suitable to rotate and suspend the rotor; (3) build a prototype system; and (4) test that system for hydraulic performance and hemolysis. In Phase II, the product version of the pump will be designed, built, and extensively tested in animal CPB and ECMO studies. PROPOSED COMMERCIAL APPLICATION: Potential commercial applications inculde cardiopulmonary bypass (CPB) circuits, postcardiotomy- assist cases, and extracorporeal membrane oxygenation (ECMO). The magnetically levitated disposable blood pump is expected to provide economical performance for short-term, single- use indications, and its reusable motor-bearing assembly is durable, for longer duration, temporary, and bridge pump applications. Additionally, it can be located on the OR table, with special catheter set, for minimally invasive surgical procedures.