Low-Cost Rotary Blood Pump with ICB Magnetic Support

带 ICB 磁力支撑的低成本旋转式血泵

• 批准号: 6689892
• 负责人: HSIANG M CHEN
• 金额: $ 30.4万
• 依托单位: FOSTER-MILLER TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-10 至 2005-07-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6689892
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomedical equipment development; circulatory assist; clinical biomedical equipment

DESCRIPTION (provided by applicant): An "Inherently Controlled Bearing" (ICB) concept has been demonstrated in a magnetically suspended rotary blood pump intended for use as a permanently implanted ventricular assist device (VAD). The ICB eliminates not only position sensors but also active feedback electronic control of the bearing coil currents, and good efficiency and high stiffness of a prototype ICB has been documented. The specific aim of this Fast-Track proposal is to demonstrate that this innovative technology can be extended to produce a very low cost, yet highly durable, pump for medium-term uses, such as extracorporeal lung support (ECLS), or bridge-to-transplant/recovery use. To accomplish this, several additional innovations will be incorporated in the pump design. Walls between the rotor and stator housings will be introduced to isolate the blood path from the now separable and reusable stators. The motor will be redesigned to provide the speed and power required for the wider range of hydraulic output, and the rotor diameter decreased, reducing viscous drag losses by more than the resulting speed increase and reducing the motor torque output required for a particular hydraulic output. Lower cost materials and manufacturing methods will be incorporated to fabricate this nonpermanent, nonimplanted pump. Success in Phase I will be a prototype with sufficient stiffness in the bearing to resist all imposed shock and vibration loads and a bearing power consumption below 2.5 W, at all operating conditions. The prototype will also demonstrate an ability to pump 5 liter/min at 100 mm-Hg pressure rise with motor power input below 8 W, an ability to pump 4 liter/min at 350 mm-Hg pressure rise with motor power below 25 W, and an ability to pump 9 liter/min at 120 mm-Hg pressure rise, with 40 W maximum power. The advantage of success here is that a common, core technology will become available for blood pump applications. Cost benefits will accrue from this commonality, and in quantities of 1000 or more per year, the simple disposable element can be sold at a price competitive with existing products. Improvements on rates of thrombus formation and bearing durability will also be realized, and the relatively small size would allow use as a wearable bridge-to-transplant/recovery device, it would also offer an alternative for small patients, for transient right ventricle support after LVAD implant, or for marketplaces that cannot afford implantable pump costs.

描述（由申请人提供）： “固有控制轴承”(ICB) 概念已在磁悬浮旋转血泵中得到验证，该血泵旨在用作永久植入的心室辅助装置 (VAD)。 ICB 不仅消除了位置传感器，还消除了轴承线圈电流的主动反馈电子控制，并且原型 ICB 具有良好的效率和高刚度。该快速通道提案的具体目标是证明这种创新技术可以扩展到生产成本非常低但高度耐用的泵，用于中期用途，例如体外肺支持（ECLS）或桥接移植/恢复用途。为了实现这一目标，泵设计中将融入一些额外的创新。将在转子和定子壳体之间引入壁，以将血液路径与现在可分离和可重复使用的定子隔离。电机将被重新设计，以提供更广泛的液压输出所需的速度和功率，并且转子直径减小，从而比由此产生的速度增加减少粘性阻力损失，并减少特定液压输出所需的电机扭矩输出。将采用成本较低的材料和制造方法来制造这种非永久性、非植入式泵。第一阶段的成功将是一个原型，其轴承具有足够的刚度，可以抵抗所有施加的冲击和振动载荷，并且在所有操作条件下轴承功耗均低于 2.5 W。该原型机还将展示在电机功率输入低于 8 W 时在 100 mm-Hg 压升下泵送 5 升/分钟的能力，在电机功率低于 25 W 时在 350 mm-Hg 压升下泵送 4 升/分钟的能力，以及在 120 mm-Hg 压升下泵送 9 升/分钟的能力，最大功率为 40 W。这里成功的优势在于，通用的核心技术将可用于血泵应用。这种共性将产生成本效益，每年数量为 1000 个或更多，这种简单的一次性元件可以以与现有产品竞争的价格出售。血栓形成率和轴承耐久性也将得到改善，相对较小的尺寸将允许用作可穿戴桥移植/恢复装置，它也将为小型患者、LVAD 植入后短暂右心室支持或无法负担植入式泵成本的市场提供替代方案。