Inherently Controlled Magnetic Bearing Rotary Blood Pump

固有控制磁力轴承旋转血泵

• 批准号: 6603406
• 负责人: HSIANG M CHEN
• 金额: $ 64.92万
• 依托单位: FOSTER-MILLER TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6603406
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomedical equipment development; circulatory assist; cow; electrical conductance; implant; magnetism; medical implant science

Description (provided by applicant): The goal of this Phase II project is to demonstrate the prototype of a fully implantable rotary ventricular assist device (VAD). This pump utilizes the advanced three-dimensional magnetic suspension for the rotor demonstrated during Phase I. This bearing system requires neither position sensors nor active feedback electronics, resulting in the simplest 3-0 magnetic bearing available for blood pumps. The bearing coils form part of a tuned inductance-capacitance-resistance (LCR) circuit. A sine wave generator powers the coil. Motion of the rotor varies the inductance and therefore tuning of the circuit such that changes in electrical current flow always occur to oppose the direction of motion. Control of the rotor position is inherent in the bearing construction and Eamshaw?s Law is satisfied. Phase I demonstrated that this bearing construct can be dynamically stable, low in power consumption, and adequately stiff to handle externally applied shock and vibration loads. During Phase II, the program will advance to design and develop a prototype implantable rotary VAD and electronics package and perform in-vivo tests and in-vitro endurance tests. Successful completion will lead directly to a Phase Ill effort and ultimately FDA approval for clinical trials. PROPOSED COMMERCIAL APPLICATION: Heart disease remains the leading cause of death and disability in the United States. Of the 600,000 Americans who die each year due to heart-related problems, about 30,000 to 60,000 could probably be saved with heart transplants. However, the shortage of donor hearts precludes this, and has stimulated the development of many mechanical heart assist and replacement devices. Should mechanical assist pumps prove sufficiently safe and reliable, the potential use to improve the quality of life for cardiac-impaired patients dramatically expands the market.

描述（由申请人提供）：该第二阶段项目的目标是 演示完全植入的旋转心室辅助的原型 设备（VAD）。该泵利用高级三维磁 在第1阶段演示的转子的悬架 不需要位置传感器也不需要主动反馈电子设备，从而 最简单的3-0磁性轴承可用于血泵。轴承线圈 构成了调谐电感抗性抗性（LCR）电路的一部分。正弦 波发电机为线圈提供动力。转子的运动改变了电感和 因此调整电路以使电流流动变化 总是发生反对运动方向。控制转子位置 轴承构建中固有的固有，而Eamshaw的定律得到满足。第一阶段 证明这种轴承构建体可以动态稳定，较低 功耗，并且足够僵硬以处理外部施加的冲击和 振动负载。在第二阶段，该计划将促进设计和 开发原型植入式旋转VAD和电子包装，并执行 体内测试和体外耐力测试。成功完成将领导 直接进行阶段不适，并最终获得FDA批准进行临床试验。 拟议的商业应用：心脏病仍然是美国死亡和残疾的主要原因。 每年由于与心脏有关的问题而死的60万美国人中，大约30,000至60,000人可能会通过心脏移植来保存。 但是，捐助者心脏的短缺无法做到这一点，并刺激了许多机械心脏辅助设备和替换设备的发展。如果机械辅助泵被证明是足够安全和​​可靠的，那么改善心脏损害患者生活质量的潜在用途会大大扩展市场。