Inherently Controlled Magnetic Bearing Rotary Blood Pump

固有控制磁力轴承旋转血泵

• 批准号: 6603406
• 负责人: HSIANG M CHEN
• 金额: $ 64.92万
• 依托单位: FOSTER-MILLER TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6603406
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomaterial development /preparation; biomaterial evaluation; biomedical equipment development; circulatory assist; cow; electrical conductance; implant; magnetism; medical implant science

Description (provided by applicant): The goal of this Phase II project is to demonstrate the prototype of a fully implantable rotary ventricular assist device (VAD). This pump utilizes the advanced three-dimensional magnetic suspension for the rotor demonstrated during Phase I. This bearing system requires neither position sensors nor active feedback electronics, resulting in the simplest 3-0 magnetic bearing available for blood pumps. The bearing coils form part of a tuned inductance-capacitance-resistance (LCR) circuit. A sine wave generator powers the coil. Motion of the rotor varies the inductance and therefore tuning of the circuit such that changes in electrical current flow always occur to oppose the direction of motion. Control of the rotor position is inherent in the bearing construction and Eamshaw?s Law is satisfied. Phase I demonstrated that this bearing construct can be dynamically stable, low in power consumption, and adequately stiff to handle externally applied shock and vibration loads. During Phase II, the program will advance to design and develop a prototype implantable rotary VAD and electronics package and perform in-vivo tests and in-vitro endurance tests. Successful completion will lead directly to a Phase Ill effort and ultimately FDA approval for clinical trials. PROPOSED COMMERCIAL APPLICATION: Heart disease remains the leading cause of death and disability in the United States. Of the 600,000 Americans who die each year due to heart-related problems, about 30,000 to 60,000 could probably be saved with heart transplants. However, the shortage of donor hearts precludes this, and has stimulated the development of many mechanical heart assist and replacement devices. Should mechanical assist pumps prove sufficiently safe and reliable, the potential use to improve the quality of life for cardiac-impaired patients dramatically expands the market.

描述（由申请人提供）：该第二阶段项目的目标是 展示完全植入式旋转心室辅助装置的原型 设备（VAD）。该泵采用先进的三维磁力 在第一阶段演示了转子悬架。该轴承系统 既不需要位置传感器也不需要有源反馈电子设备，从而 适用于血泵的最简单的 3-0 磁力轴承。轴承线圈 构成调谐电感电容电阻（LCR）电路的一部分。正弦 波发生器为线圈供电。转子的运动会改变电感和 因此调整电路，使电流发生变化 总是发生与运动方向相反的情况。转子位置的控制 是轴承结构所固有的，并且满足伊姆肖定律。第一阶段 证明了这种轴承结构可以是动态稳定的，低 功耗，并且足够坚硬以应对外部施加的冲击和 振动载荷。在第二阶段，该计划将推进设计和 开发原型植入式旋转 VAD 和电子封装并执行 体内测试和体外耐久性测试。顺利完成将引领 直接进入 III 期工作并最终获得 FDA 批准进行临床试验。 拟议的商业应用：心脏病仍然是美国死亡和残疾的主要原因。 每年有 60 万美国人死于心脏相关问题，其中约 3 万到 6 万可能可以通过心脏移植获救。 然而，供体心脏的短缺阻碍了这一点，并刺激了许多机械心脏辅助和替代设备的发展。如果机械辅助泵被证明足够安全和​​可靠，那么其用于改善心脏受损患者的生活质量的潜在用途将极大地扩大市场。