Fully Implantable Mini-Mixed-Flow Pump

描述(由申请人提供)： 这一快速通道赠款的第一阶段将成功地展示一种用于永久性植入性、极小的右室辅助装置(RVAD)的微型混流泵概念。第二阶段的目标是开发和演示产品原型。原型泵的设计将根据第一阶段的经验进行优化，并将设计和制造一个定制的电机控制器。该系统将在试验台上进行性能、溶血和长期耐力测试。将在小牛身上进行一系列RVAD演示测试。还将创建一个双VAD系统并进行台架测试；该双VAD将RVAD与磁螺杆VAD和磁螺杆TAH的支持组件结合在一起。作为拟议工作的结果，完全可植入的RVAD将可用于集成到双VAD系统中。这将为每年估计需要双侧脑室辅助的10,000至20,000名患者提供一种有效的治疗方式。

DESCRIPTION (provided by applicant): Phase I of this Fast-Track grant will successfully demonstrate a Mini-Mixed-Flow pump concept for a permanently implantable, extremely small right ventricular assist device (RVAD). The goal of Phase II is to develop and demonstrate a product prototype. The prototype pump design will be optimized, based on Phase I experience, and a custom motor controller will be designed and fabricated. The system will be bench tested for performance, hemolysis, and long-term endurance. A series of RVAD demonstration tests in calves will be performed. A Bi-VAD system will also be created and bench tested; this Bi-VAD will combine the RVAD with a MagScrew VAD and the supporting components of a MagScrew TAH. As a result of the proposed effort, a fully implantable RVAD will become available for integration into a Bi-VAD system. This will provide an effective treatment modality for the 10,000 to 20,000 patients per year who are estimated to need bi-ventricular assistance.