Compact and Durable Catheter Pump: Phase II

紧凑耐用的导管泵：第二阶段

• 批准号: 6644510
• 负责人: HSIANG M CHEN
• 金额: $ 64.68万
• 依托单位: FOSTER-MILLER TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644510
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomedical equipment development; catheterization; circulatory assist; extracorporeal circulation; hemolysis; implant; mechanical pressure; medical implant science; surgery material /equipment; temperature

DESCRIPTION (provided by applicant): The fundamental goal of this research is to develop an intravascular catheter pump of adequate output, appropriate size, high blood compatibility, and adequate durability to be used as a temporary assist pump in the operating room or interventional cardiology lab. The Phase I program demonstrated the ability to meet this goal by satisfying all success criteria. Results so exceeded expectations that it is clear that this platform technology can be extended into many applications beyond the original intent. Since pump performance is no longer a fundamental issue, meeting production specifications with a robust design is a key objective of Phase II. The result will be a production-suitable pump prototype that meets quantitative goals for performance, while demonstrating behaviors, handling characteristics, and performance values suitable for clinical use. The initial market evolves from the cardiac minimally invasive surgery field, which was estimated to include over 30,000 cases in 2000 and continues to grow. Other applications would include a permanently implantable right ventricular assist device, a pediatric assist device, and a peripherally inserted temporary left ventricular assist device. With appropriate work, the basic design concept seems adaptable to all these applications in future programs.

描述（由申请人提供）： 本研究的基本目标是开发一种具有足够输出、适当尺寸、高血液相容性和足够耐用性的血管内导管泵，用作手术室或介入心脏病学实验室的临时辅助泵。第一阶段计划证明了通过满足所有成功标准来实现这一目标的能力。结果超出了预期，很明显，该平台技术可以扩展到许多应用程序，超出了最初的意图。由于泵的性能不再是一个基本问题，因此通过稳健的设计满足生产规格是第二阶段的关键目标。结果将是一个适合生产的泵原型，满足性能的定量目标，同时证明适合临床使用的行为，处理特性和性能值。最初的市场是从心脏微创手术领域发展而来的，2000年估计有超过30，000例病例，并继续增长。其他应用包括永久植入式右心室辅助装置、儿科辅助装置和外周插入式临时左心室辅助装置。通过适当的工作，基本的设计概念似乎适用于未来计划中的所有这些应用。