MRC Centre for Global Infectious Disease Analysis

MRC 全球传染病分析中心

• 批准号: MR/R015600/1
• 负责人: Neil Ferguson
• 金额: $ 574.18万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FR015600%2F1
• 关键词: MRC; Centre; Global; Infectious; Disease

The continuing threat from new infectious diseases has been highlighted in recent years by the emergence of MERS-coronavirus in the Middle East, Ebola in West Africa and Zika in Latin America. Preparing for and responding to such threats is a priority for public health agencies and governments worldwide. Equally importantly, as scientific research delivers new approaches to controlling existing infectious diseases such as malaria, HIV, tuberculosis and polio, there is a need to determine what interventions are likely to work best to limit the disease and illness caused by a specific disease in a particular setting.In this context, computer modelling of the spread of diseases in populations coupled with scientifically rigorous data analysis have proven themselves as powerful tools for giving insight into how diseases spread and what can be done to limit that control that spread. The Centre for Global Infectious Disease Analysis undertakes research on these scientific methods and applies them to disease threats of concern. A key feature of the Centre is the close links it has made with with public health agencies - such as the Public Health England, the Centers for Disease Control and Prevention in the US (CDC), and the World Health Organization (WHO) - organisations which have to formulate and implement strategies to control infectious diseases. Senior scientists in the Centre are world-leaders in infectious disease modelling and analysis. They have broad experience in responding to real epidemics, and undertaking epidemiological research on endemic diseases (such as malaria, HIV, tuberculosis and polio). Their work directly influences disease control policy through the many interactions the Centre has with public health organisations and governments. Funding provided by MRC and Imperial College has allowed dedicated investment into the development of close collaborative partnerships with PHE, CDC and WHO and governments and research centres in many low and middle income countries (LMICs). We also work closely with other important organisations who work on improving health in LMICs (notably the Bill and Melinda Gates Foundation, The Global Fund and Gavi). With each, our collaborative research has both scientific interest to Centre researchers and contributes to the evidence base for public health decisions. Centre funding supports a core technical capacity available to all projects and pays for dedicated liaison staff who facilitate and enhance our partnerships with major global health organisations and LMICs. MRC funding has also facilitated a greater focus on collaboration, training and career development within the Centre - training the next generation of quantitative infectious disease epidemiologists. We are also involved in increasing knowledge of advanced modelling methods in public health institutions and the wider infectious disease research community, and so have run a large number of introductory short-courses and workshops (in 13 countries in the last 5 years)This applied activity depends on more fundamental research undertaken in the Centre on the transmission dynamics of different diseases, how diseases evolve genetically over time, and on analysing new approaches to control or treat diseases. This research is interdisciplinary, with Centre researchers working with leading clinical and experimental scientists around the world.Continued Centre funding will allow existing partnerships to be sustained and enhanced, and new collaborations with researchers and health agencies in LMICs to be developed. By supporting PhD training and postdoctoral career development, it will also continue to expand the UK skill base in mathematical modelling and advanced analysis applied to health problems. Last, continued MRC support will pump-prime new priority research areas, including work on improving the development of new vaccines and on tackling the global challenge posed by antimicrobial resistance.

近年来，中东中东地区出现MERS冠状病毒、西非出现埃博拉病毒和拉丁美洲出现寨卡病毒，突显了新传染病的持续威胁。为这些威胁做好准备并作出反应是全世界公共卫生机构和政府的优先事项。同样重要的是，由于科学研究为控制疟疾、艾滋病毒、结核病和小儿麻痹症等现有传染病提供了新的办法，因此有必要确定哪些干预措施可能最有效地限制疾病和特定环境下特定疾病造成的疾病。计算机模拟疾病在人群中的传播，加上科学上严格的数据分析，已证明是深入了解疾病传播方式的有力工具。以及如何限制这种控制的蔓延。全球传染病分析中心对这些科学方法进行研究，并将其应用于令人关切的疾病威胁。该中心的一个主要特点是与公共卫生机构建立了密切的联系，例如英国公共卫生部、美国疾病控制和预防中心（CDC）和世界卫生组织（WHO），这些组织必须制定和实施控制传染病的策略。该中心的高级科学家是传染病建模和分析领域的世界领导者。它们在应对真实的流行病和对地方病（如疟疾、艾滋病毒、结核病和小儿麻痹症）进行流行病学研究方面具有广泛的经验。他们的工作通过中心与公共卫生组织和政府的许多互动直接影响疾病控制政策。MRC和帝国理工学院提供的资金使我们能够专门投资于与PHE，CDC和WHO以及许多低收入和中等收入国家（LMIC）的政府和研究中心建立密切的合作伙伴关系。我们还与致力于改善中低收入国家健康状况的其他重要组织（特别是比尔和梅林达·盖茨基金会，全球基金和Gavi）密切合作。与每一个，我们的合作研究既有科学兴趣中心的研究人员，并有助于公共卫生决策的证据基础。中心资金支持所有项目的核心技术能力，并支付专门的联络人员，他们促进和加强我们与主要全球卫生组织和LMIC的伙伴关系。MRC的资助还促进了中心内部更加注重协作、培训和职业发展-培训下一代定量传染病流行病学家。我们还参与提高公共卫生机构和更广泛的传染病研究界对先进建模方法的认识，因此举办了大量介绍性短期课程和讲习班（过去5年在13个国家开展）这项应用活动取决于中心对不同疾病的传播动力学、疾病如何随着时间的推移在遗传上演变、以及分析控制或治疗疾病的新方法。这项研究是跨学科的，中心的研究人员与世界各地领先的临床和实验科学家合作。中心继续提供资金将使现有的伙伴关系得以维持和加强，并与中低收入国家的研究人员和卫生机构建立新的合作关系。通过支持博士培训和博士后职业发展，它还将继续扩大英国在数学建模和应用于健康问题的高级分析方面的技能基础。最后，MRC的持续支持将推动新的优先研究领域，包括改进新疫苗开发和应对抗菌素耐药性带来的全球挑战。

项目成果

Explosive nosocomial outbreak of SARS-CoV-2 in a rehabilitation clinic: the limits of genomics for outbreak reconstruction.

SARS-COV-2在康复诊所的爆炸性医学院爆发：爆发重建的基因组学的局限性。

• DOI: 10.1016/j.jhin.2021.07.013
• 发表时间: 2021-11
• 期刊: The Journal of hospital infection
• 作者: Abbas M;Robalo Nunes T;Cori A;Cordey S;Laubscher F;Baggio S;Jombart T;Iten A;Vieux L;Teixeira D;Perez M;Pittet D;Frangos E;Graf CE;Zingg W;Harbarth S
• 通讯作者: Harbarth S

Surveillance for Azole-Resistant Aspergillus fumigatus in a Centralized Diagnostic Mycology Service, London, United Kingdom, 1998-2017.

• DOI: 10.3389/fmicb.2018.02234
• 发表时间: 2018
• 期刊: Frontiers in microbiology
• 影响因子: 5.2
• 作者: Abdolrasouli A;Petrou MA;Park H;Rhodes JL;Rawson TM;Moore LSP;Donaldson H;Holmes AH;Fisher MC;Armstrong-James D
• 通讯作者: Armstrong-James D

PANINI: Pangenome Neighbour Identification for Bacterial Populations

• DOI: 10.1099/mgen.0.000220
• 发表时间: 2019-04-01
• 期刊: MICROBIAL GENOMICS
• 影响因子: 3.9
• 作者: Abudahab, Khalil;Prada, Joaquin M.;Aanensen, David M.
• 通讯作者: Aanensen, David M.

Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study.

• DOI: 10.7554/elife.76854
• 发表时间: 2022-07-19
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Abbas, Mohamed;Cori, Anne;Cordey, Samuel;Laubscher, Florian;Robalo Nunes, Tomas;Myall, Ashleigh;Salamun, Julien;Huber, Philippe;Zekry, Dina;Prendki, Virginie;Iten, Anne;Vieux, Laure;Sauvan, Valerie;Graf, Christophe E.;Harbarth, Stephan
• 通讯作者: Harbarth, Stephan