INTRA-CORTICAL NEURO RECORDING TELEMETER

皮质内神经记录遥测仪

• 批准号: 2842433
• 负责人: DAVID J EDELL
• 金额: $ 28.96万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2842433
• 关键词: Macaca mulatta; bioengineering /biomedical engineering; brain electrical activity; cats; dogs; electrodes; electronic recording system; implant; laboratory rabbit; medical implant science; microelectrodes; neuroanatomy; neurophysiology; pia mater; technology /technique development; telemetry

A new technology will be developed for long term neural recordings using intra-cortical microelectrode arrays. One important desired feature of long-term neural recordings is the ability to record from the same neurons from month to month or year to year. However, with existing technology this is very difficult to accomplish. One possible reason may be motion of the microelectrode array relative to the neural tissue caused by wiring from the arrays to the skull. A small, lightweight, wireless neural recording telemeter embedded in the pia so it could move with the brain may exhibit improved capacity for reproducibly recording from single units for long times. The objective of the proposed work is to develop and evaluate a tetherless, small, lightweight 16-channel telemeter. This telemeter will be attached directly to intra-cortical microelectrode arrays for placement on the pia. The packaging will be of the appropriate materials and shape to encourage encapsulation and stabilization by the pia. Data and power will be telemetered through the skull to external instrumentation. Rabbit, dog, cat and monkey will be used as animal models in this study to evaluate the technology in a variety of circumstances and with a variety of existing protocols. Metrics of the technology include: long term assessment of the electrical properties of the system; length of time that single units can be maintained; amplitude stability of single units over time; neuron density about the microelectrodes; degree of encapsulation by the pia; migration distance of the microelectrodes; and evidence of micro-hemorrhages. The primary application of this technology will be to facilitate long term intra-cortical chronic recordings for neuroscience. Perhaps when the technology is fully developed, it will be possible to apply it to rehabilitation of the spinal cord injured. An example would be for extraction of motor control information for control of functional electrical stimulation systems.

一种新的技术将被开发用于使用皮层内微电极阵列的长期神经记录。 长期神经记录的一个重要的期望特征是能够从相同的神经元逐月或年复一年地记录。 然而，利用现有技术，这是很难实现的。 一个可能的原因可能是由从阵列到颅骨的布线引起的微电极阵列相对于神经组织的运动。 一个小的，重量轻的，无线神经记录遥测仪嵌入软脑膜，使它可以移动与大脑可能会表现出改善的能力，可重复记录从单个单位长时间。建议的工作的目标是开发和评估一个无系绳，小型，轻便的16通道遥测仪。 该遥测仪将直接连接到皮质内微电极阵列，以放置在软脑膜上。 包装将采用适当的材料和形状，以促进软包装的封装和稳定。 数据和能量将通过颅骨传送到外部仪器。本研究将使用兔、犬、猫和猴作为动物模型，以在各种情况下使用各种现有方案评价该技术。 该技术的评估包括：系统电性能的长期评估;单个单元可以维持的时间长度;单个单元随时间的振幅稳定性;微电极周围的神经元密度;软脑膜包裹的程度;微电极的迁移距离;以及微血管扩张的证据。这项技术的主要应用将是促进神经科学的长期皮层内慢性记录。也许当这项技术完全发展时，将有可能将其应用于脊髓损伤的康复。 一个示例是提取用于控制功能性电刺激系统的电机控制信息。